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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (4): 471-474.

• 研究原著 • 上一篇    下一篇

阿齐霉素加左氧氟沙星治疗传染性非典型肺炎疑似病人成本-效果分析

袁建章, 邓哲彤, 杨秀文, 汪得喜, 王雄文   

  1. 广州市红十字会医院, 暨南大学医学院第四附属医院, 广州 510220, 广东
  • 收稿日期:2004-06-08 修回日期:2004-08-10 出版日期:2005-04-26 发布日期:2020-11-19
  • 通讯作者: 袁建章,男, 副主任医师, 主要研究方向:慢性阻塞性肺疾病。Tel:(0) 13719343354 E-mail:fc2334@163.com

Cost-effective analysis about treatment of azithromycin and levo-ofloxacin in suspected SARS patients

YUAN Jian-zhang, DENG Zhe-tong, YANG Xiu-wen, WANG De-xi, WANG Xiong-wen   

  1. Gangzhou Red-crossHospital, the Fourth Affiliated Hospital of Medical College, Jinan University, Guangzhou 510220,Guangdong, China
  • Received:2004-06-08 Revised:2004-08-10 Online:2005-04-26 Published:2020-11-19

摘要: 目的: 探讨阿齐霉素加左氧氟沙星治疗传染性非典型肺炎(SARS) 疑似病人的成本-效果。方法: 静脉使用阿齐霉素加口服左氧氟沙星, 根据病人对治疗的反应, 将疑似 SARS 的 75 例病人分成 SARS临床诊断病例组 18 例、非SARS 组 57例(SARS 临床排除病例 51例 、疑似细菌性肺炎组6 例), 最后统计各组病人的发热天数 、入院体温、退热时间、住院天数和总费用。结果: SARS 组与非 SARS 组病人的年龄、入院体温无显著的统计学意义(P>0.05);治疗3 d, 非SARS 组有 51例病人基本排除 SARS 病例;最后非 SARS 组的住院时间为 8.0 ±4.0 d, 明显低于SARS 临床诊断病例组的 13.4±4.8 d(P<0.01);非SARS 组的平均住院费用是 4973 ±3410 元, 明显低于SARS 临床诊断病例组的 7363 ±2835 元(P<0.01)。各组病人全部康复出院。追踪观察排除SARS 患者中临床上没有漏诊 1 例SARS 病人。治疗费用远远低于广州市参保非典病人和疑似病人平均医疗费用。结论: 阿齐霉素针静脉滴注加口服左氧氟沙星, 可以较快地从临床上排除 SARS 病例, 而且费用低廉, 符合基本保健制度的精神, 是一种值得在临床继续使用、观察和完善的治疗方法。

关键词: 传染, 肺炎, 阿齐霉素, 左氧氟沙星, 非典型

Abstract: AIM: To explore the cost-effective quali-ty about the treatment of azithromycin and levo-ofloxacin in suspected contagious atypical pneumonia (SARS) pa-tients.METHODS: Azithromycin and levo-ofloxacin were administered intravenously and orally, respectively. All suspected SARS patients (n =75) were divided into three groups according to their responses to the therapy: clinically diagnosed patients (group A, n =18), clini-cally excluded patients (group B, n =51), and patients with suspected bacterial pneumonia (group C, n =6). Duration of fever, temperature at admission, time of fever reduction, duration of hospitalization and total expenditure were recorded for each patient. RESULTS: There were no differences (P>0.05) in age and temperature at ad-mission between SARS group (group A) and non-SARS group (group B and C). 51 patients were excluded from SARS after 3-day treatment. The duration of hospitaliza-tion in non-SARS group was significantly shorter than that of group A (8.0 ±4.0 days vs 13.4 ±4.8 days, P<0.01), and the total medical expenditure of the former was markedly lower than that of the latter (4973 ±3410 yuan vs 7363±2835yuan, P <0.01). All patientswere restored well. A follow-up study showed that no patients of non-SARS group were misdiagnosed. The therapeutic expenditure for all 3groupswas far lower than the average cost for SARS and suspected SARS patients of Guangzhou City. CONCLUSION: Treatment with intravenous ad-ministration of azithromycin and oral administration of lev-o-ofloxacin provides an effective method to early exclude the SARS-free patients, and it is cheap according with the basic sanitary hygiene rules.This protocol deserves long-term clinical utilization, investigation and further im-provement.

Key words: contagion pneumonia, azithromycin, lev-o-ofloxacin, atypical

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