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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (7): 804-807.

• 研究原著 • 上一篇    下一篇

竹叶椒片对大肠杆菌所致大鼠慢性盆腔炎的治疗作用

孙晓玮, 程体娟1, 罗慧英1, 强宇靖1, 方彩霞1, 张文斌2   

  1. 兰州大学基础医学院病理解剖教研室,1药学院药理教研室, 兰州730000, 甘肃;
    2上海中医药大学科技实验中心, 上海201203
  • 收稿日期:2005-05-31 修回日期:2005-06-13 出版日期:2005-07-26 发布日期:2020-11-10
  • 通讯作者: 程体娟, 硕士, 教授, 硕士生导师, 研究方向:中药药理。
  • 作者简介:孙晓玮, 女, 硕士, 讲师, 研究方向:器官纤维化。Tel:0931-3627573 E-mail: dweiwang@sina.com

Therapeutic effects of Zhuyejiao tablets on chronic pelvic inflammation induced by coliform in rats

SUN Xiao-wei, CHENG Ti-juan1, LUO Hui-ying1, QIANG Yu-jing1, FANG Cai-xia1, ZHANG Wen-bin2   

  1. Department of Pathology, Basic Medical School, 1Department of Pharmacology, Pharmacy college, Lanzhou University, Lanzhou 730000, Gaosu, China;
    2Experimental center of science and technique Shanghai Traditional Medical and Medicine University, Shanghai 201203, China
  • Received:2005-05-31 Revised:2005-06-13 Online:2005-07-26 Published:2020-11-10

摘要: 目的: 研究竹叶椒片对大肠杆菌所致大鼠慢性盆腔炎的治疗作用。方法: 采用大肠杆菌O-B4 标准菌株的菌液注入大鼠子宫内, 制备大鼠慢性盆腔炎动物模型。大鼠分6 组:假手术组、模型组、竹叶椒大、中、小剂量组和妇科千金片组, 分别给予相应药物, 每天ig 2 次, 连续21 d 。然后测定大鼠免疫功能并进行大鼠子宫组织形态学观察。结果: 给药组大鼠血清凝集素效价显著升高, 淋巴细胞转化指数也明显提高, 组织形态学观察发现给药组大鼠慢性盆腔炎病理改变明显减轻。结论: 竹叶椒片对大肠杆菌所致大鼠慢性盆腔炎有明显治疗作用。

关键词: 竹叶椒, 慢性盆腔炎, 大肠杆菌O-B4, 免疫功能, 组织形态学

Abstract: AIM: To investigate the therapeutic effects of Zhuyejiao tablets (Tab. ZYJ) on chronic pelvic inflammation (CPI) induced by coliform in rats. METHODS: The CPI model was made by injecting coliform OB4 standard strains in the uterus of rat. Animals were randomly divided into six groups and drugs were administered for 21 days, bid, respectively. The immune function of animals was measured and the uterus was pathologically observed. RESULTS: The level of serum agglutinin and lymphocyte transformation index markedly increased in all ZYJ groups. Morphological investigation also revealed the alleviation of inflammation in ZYJ groups. CONCLUTION: ZYJ has therapeutic effects on chronic pelvic inflammation in rats.

Key words: Zhuyejiao tablets, chronic pelvic inflammation, coliform O-B4, immune function, morphology

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