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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (9): 966-969.

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外周NMDA受体在疼痛发生及药物干预中的作用

虞雪融, 黄宇光   

  1. 中国医学科学院中国协和医科大学北京协和医院麻醉科, 北京 100730
  • 收稿日期:2005-06-25 修回日期:2005-08-12 发布日期:2020-11-22
  • 通讯作者: 黄宇光,男,教授,博士生导师,研究方向:疼痛基础和临床。Tel:010-65295580 E-mail:pumchhyg@yahoo.com.cn
  • 作者简介:虞雪融,女,医学博士,主治医师。Tel:(0)13651370641 E-mail:yxr313@yahoo.com.cn

Role of peripheral NMDA receptor in pain occurrence and management

YU Xue-rong, HUANG Yu-guang   

  1. Department of Anesthesiology, PekingUnion Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China
  • Received:2005-06-25 Revised:2005-08-12 Published:2020-11-22

摘要: NMDA(N-甲酰-D 天门冬氨酸)受体是一种离子型谷氨酸受体, 广泛存在于外周躯体或内脏的痛觉传导通路上。外周NMDA 受体的活化或表达的改变与疼痛发生发展密切相关, 外周局部使用NMDA 受体拮抗剂可有效缓解或预防疼痛, 并能增加阿片类药物的镇痛效果, 此种用药方式可减少药物作用于中枢神经系统所导致的副作用, 是今后疼痛治疗研究的重要方向。

关键词: NMDA 受体, 外周, 疼痛发生, 疼痛治疗

Abstract: NMDA(N-Methyl-D-Aspartate)receptor is a kind of ionotropic receptors, which have been widely localized in peripheral somatic tissues and visceral pain pathways.The activation or expression changes of peripheral NMDA receptor may play an important role in pain occurrence.Peripheral administration of NMDA receptor antagonist can alleviate or prevent pain and enhance the analgesic effect of opiate.This method of administration can reduce the side effect of central action induced by the drug.It will be an important research direction of pain management.

Key words: NMDA receptor, peripheral, pain occurrence, pain management

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