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中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (1): 74-77.

• 研究原著 • 上一篇    下一篇

氟西汀治疗脑卒中后抑郁对照研究的 Meta 分析

蒋亚斌   

  1. 暨南大学附属第一医院急诊科, 广州 510632, 广东
  • 收稿日期:2005-08-22 修回日期:2005-10-27 出版日期:2006-01-06 发布日期:2020-10-23
  • 通讯作者: 蒋亚斌, 通讯作者, 男, 医学硕士, 副主任医师, 研究方向:脑血管病及 急诊医学。 Tel:020-38688102 E-mail:tjiangyb@jnu.edu.cn

Meta-analysis of effectiveness of fluoxetine in treatment of post-stroke de- pression

JIANG Ya-bin   

  1. Department of Emergency , First Affiliated Hospital of J inan University, Guangzhou 510632 , Guangdong, China
  • Received:2005-08-22 Revised:2005-10-27 Online:2006-01-06 Published:2020-10-23

摘要: 目的:进一步了解氟西汀治疗卒中后抑郁 ( post-stroke depression , PSD) 的临床疗效和安全性 。 方法:应用 Meta 分析对 13 项研究氟西汀治疗 PSD 的对照研究进行再分析, 评价其综合显著性差异和 效应大小。结果:PSD 患者氟西汀治疗前后的汉密 顿抑郁量表(HAMD) 、临床神经功能缺损程度( CSS) 及日常生活能力( ADL) Barthel 指数( BI) 评分比较, 均有显著性差异( P <0 .05) ;效应大小 :d平均 均 > 0 .8 。氟西汀治疗组与对照组抑郁症状 、神经功能及 日常生活能力改善程度的组间比较, 均有显著性差 异( P <0 .05) ;效应大小 :d平均 均 >0 .8 。结论 :氟西 汀对 PSD 患者的抑郁症状 、神经功能缺损和日常生 活能力均有显著的改善作用, 且不良反应少。

关键词: 脑卒中 , 抑郁, 氟西汀, 神经功能, Meta 分 析

Abstract: AIM :To further investigate the effective- ness and safety of fluoxetine in treatment of post-stroke depression ( PSD) .METHODS :The effectiveness and safety of fluoxetine in treatment of PSD patients in 13 con- trolled studies were analyzed by meta-analysis again in or- der to assess the comprehensively significant differences and effect size ( ES ) .RESULTS:( 1) The scores of Hamilton, and degrees of neurological functional defect and Barthel index in PSD patients before and after treat- ment with fluoxetine had significant difference ( P < 0 .0005) , and ES :dmean >0 .8 .( 2) Improving degrees of depression symptom, neurological functional defect and activity of daily living scale ( ADL) between fluoxetine treatment group and control group had significant differ- ence ( P <0 .0005) , and ES :dmean >0 .8 .CONCLU- SION:Fluoxetine can significantly ameliorate the depres- sion symptom, neurological functional defect and ADL of patients with PSD, and it has few side effects .

Key words: stroke , depression , fluoxetine, neuro- logical function , Meta-analysis

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