盐酸戊乙奎醚对沙土鼠前脑缺血再灌注损伤的保护作用

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (4): 453-457.

盐酸戊乙奎醚对沙土鼠前脑缺血再灌注损伤的保护作用

马腾飞, 靳榕, 张晶, 谷淑玲, 段世明

徐州医学院药理教研室, 徐州221002, 江苏

收稿日期:2005-12-23 修回日期:2006-03-07 出版日期:2006-04-26 发布日期:2020-12-08
通讯作者: 谷淑玲, 女, 教授, 硕士生导师, 研究方向:神经、心血管药理学。Tel:0516-83262107 　E-mail:gushling@163.com
作者简介:马腾飞, 男, 硕士, 助教, 研究方向:神经、心血管药理学。Tel:0516-83262106 　E-mail:Tengfmtf@yahoo.com.cn

Protective effects of penehyclidine hydrochloride on transient forebrain ischemia reperfusion injury in gerbils

MA Teng-fei, JIN Rong, ZHANG Jing, GU Shu-ling, DUAN Shi-ming

Department of Pharmacology, Xuzhou Medical College, Xuzhou 221002, Jiangsu, China

Received:2005-12-23 Revised:2006-03-07 Online:2006-04-26 Published:2020-12-08

摘要/Abstract

摘要： 目的:研究盐酸戊乙奎醚(PHC)对沙土鼠前脑缺血再灌注损伤的保护作用。方法:采用沙土鼠双侧颈总动脉阻断模型, 观察PHC 对沙土鼠前脑缺血再灌注后卒中症状、病理形态的影响, 并测定超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。结果:与模型组比较, PHC 0.08 、0.24 mg·kg^-1 组与阿托品组均明显降低动物缺血再灌注6 h 卒中指数, 同时PHC 可使大脑皮质及海马组织中SOD 活性明显升高、MDA 含量明显降低。PHC 可以减轻再灌注3 d后海马神经元锥体细胞损伤程度。结论:PHC 对沙土鼠前脑缺血再灌注损伤具有保护作用。

关键词: 脑缺血, 沙土鼠, M受体, 超氧化物歧化酶, 丙二醛

Abstract: AIM: To study the protective effects of penehyclidine hydrochloride (PHC)on transient forebrain ischemia reperfusion injury in gerbils.METHODS: The model of transient forebrain ischemia reperfusion was established in gerbils by bilateral carotid artery clamping. The effects of PHC on neurological function scores and the morphous of hippocampal pyramidal neuron of gerbils were observed after receiving transient forebrain ischemia reper-fusion.SOD activities and contents of MDA in the hippocampus and cortex of gerbils were measured.RESULTS: In the groups of PHC 0.08, 0.24 mg·kg ^-1 and atropine, the stroke index was decreased, compared with the ischemia-reperfusion group after the gerbils received transient forebrain ischemia reperfusion for six hours. PHC could reduce the degree of injury in hippocampal pyramidal neuron after ischemia reperfusion for three days. CONCLUSION: PHC has protective effects on transient forebrain ischemia reperfusion injury in gerbils.

Key words: cerebral ischemia, gerbils, muscarinic receptors, superoxide dismutase, malondialdehyde

中图分类号:

R965.1

马腾飞, 靳榕, 张晶, 谷淑玲, 段世明. 盐酸戊乙奎醚对沙土鼠前脑缺血再灌注损伤的保护作用[J]. 中国临床药理学与治疗学, 2006, 11(4): 453-457.

MA Teng-fei, JIN Rong, ZHANG Jing, GU Shu-ling, DUAN Shi-ming. Protective effects of penehyclidine hydrochloride on transient forebrain ischemia reperfusion injury in gerbils[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(4): 453-457.

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