反复呼吸道感染患儿免疫功能变化及核酪注射治疗疗效观察

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (4): 467-469.

反复呼吸道感染患儿免疫功能变化及核酪注射治疗疗效观察

吴琳, 崔敏娴, 夏晓青

浙江中医学院附属第二医院儿科, 杭州310006, 浙江

收稿日期:2006-02-18 修回日期:2006-03-23 出版日期:2006-04-26 发布日期:2020-12-08
通讯作者: 吴琳, 女, 副主任医师, 主要从事小儿呼吸系统疾病的研究工作。Tel:0571-85827603 　E-mail:wulin402@hotmail.com

Changes in immune function of children patients with repeated respiratory infection and effect of treatment with nucleotide and casein injection

WU Lin, CUI Min-xian, XIA Xiao-qing

Department of Pediatrics, the Second Affiliated Hospital, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang, China

Received:2006-02-18 Revised:2006-03-23 Online:2006-04-26 Published:2020-12-08

摘要/Abstract

摘要： 目的:探讨反复呼吸道感染(RRI) 患儿免疫功能变化及核酪注射液对其的影响。方法:将45 例RRI 患儿设为RRI 组, 用核酪注射液治疗, 对照组32例为非RRI 的急性呼吸道感染患儿, 观察疗效及治疗前后血免疫球蛋白、T 细胞亚群变化及植物血凝素(PHA) 皮试反应强度。结果:RRI 患儿IgA 、IgG 明显低于对照组(P <0.01 、P <0.05), 治疗后IgA 较治疗前升高(P <0.05)。RRI 患儿CD₄ 、CD₄/CD₈ 、NK细胞明显低于对照组(P <0.05 、P <0.01), 治疗后CD₄ 、NK 细胞较治疗前升高(P <0.05)。RRI 患儿PHA 红晕直径较对照组小(P <0.05), 治疗后较治疗前增加(P <0.05)。结论:RRI 患儿细胞免疫、体液免疫功能均下降, 核酪注射液具有提高和调节细胞免疫和体液免疫功能的作用。

关键词: 小儿, 反复呼吸道感染, 免疫功能, 核酪注射液

Abstract: AIM: To explore the changes in immune function children patients with repeated respiratory infection (RRI) and the influence of nucleotide and casein injection on it.METHODS: 45 patients with RRI were arranged in therapy group and were injected with nucleotide and casein injection.32 patients with acute respiratory infection were arranged in control group who were not injected with nucleotide and casein injection.The effect of treatment, change of IgA, IgG, IgM, T-lymphocyle subgroups and reaction intensity of PHA were observed.RESULTS: There were very significant decline of IgA and IgG level (P <0.01, P <0.05) in RRI children than those in control group.The IgA level in RRI increased obviously after treatment with nucleotide and casein injection (P <0.05).There were very significant decline of CD₄, CD₄/CD₈ and NK cells levels (P <0.05, P < 0.01) in RRI children than those in control group.The CD₄, NK cells levels in RRI obviously increased after treatment with nucleotide and casein injection (P < 0.05).The roseola diameter of PHA in RRI children declined significantly (P <0.05).There were obviously increase in roseola diameter of PHA after treatment with nucleotide and casein injection (P <0.05).CONCLUSION: Nucleotide and casein injection boosts and improves cell immunity and fluid immunity.

Key words: children, repeated respiratory infection, immune function, nucleotide and casein injection

中图分类号:

R969.4

吴琳, 崔敏娴, 夏晓青. 反复呼吸道感染患儿免疫功能变化及核酪注射治疗疗效观察[J]. 中国临床药理学与治疗学, 2006, 11(4): 467-469.

WU Lin, CUI Min-xian, XIA Xiao-qing. Changes in immune function of children patients with repeated respiratory infection and effect of treatment with nucleotide and casein injection[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(4): 467-469.

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