青蒿素类药物的药理作用新进展

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (6): 615-620.

青蒿素类药物的药理作用新进展

郭燕, 王俊, 陈正堂

第三军医大学附属新桥医院全军肿瘤研究所, 重庆 400037

收稿日期:2006-04-12 修回日期:2006-04-30 出版日期:2006-06-26 发布日期:2020-12-04
通讯作者: 陈正堂,男,教授,医学博士,博士生导师,研究方向:恶性肿瘤的防治。Tel:023-68755626 E-mail:chenzhengtang@mail.tmmu.com.cn
作者简介:郭燕,女,硕士研究生,研究方向:肺癌防治研究。Tel:13452126698 E-mail:gy79@mail.tmmu.com.cn

Recent advancement in pharmacological effects of artemisinin and its derivatives

GUO Yan, WANG Jun, CHEN Zheng-tang

Cancer Institute of People's Liberation Army, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China

Received:2006-04-12 Revised:2006-04-30 Online:2006-06-26 Published:2020-12-04

摘要/Abstract

摘要： 青蒿素是从植物黄花蒿中提取的抗疟疾的活性成份, 目前在临床上广泛用于治疗疟疾。近些年研究发现青蒿素不仅可以抗寄生虫, 包括疟原虫、血吸虫, 而且具有显著的抗炎、调节免疫和抗肿瘤等多方面的药理作用。本文在介绍青蒿素抗疟疾作用、应用和作用机制的基础上, 对近年来青蒿素类药物的其它主要生物学作用研究的现状进行综述。

关键词: 青蒿素, 抗疟疾, 抗肿瘤, 脓毒症, 抗寄生虫

Abstract: Artemisinin, an active compound extracted from Artemisia annua, L.together with its derivatives are widely used as anti-malarial drugs.In recent years, artemisinin and many of its analogs were reported to possess some other effects such as anti-inflammatory, immuno-modulation and antitumor activities besides antiparasitic actions against Plasmodium falciparum and Schistosoma.Based on an introduction of the conventional actions and mechanisms of these drugs, we reviewed the recent progress of their new biological actions in this article.

Key words: artemisinin, anti-malarial, anti-tumor, sepsis, antiparasitic

中图分类号:

R969
R285.6

郭燕, 王俊, 陈正堂. 青蒿素类药物的药理作用新进展[J]. 中国临床药理学与治疗学, 2006, 11(6): 615-620.

GUO Yan, WANG Jun, CHEN Zheng-tang. Recent advancement in pharmacological effects of artemisinin and its derivatives[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(6): 615-620.

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