关键词: 复方硫酸铝注射液, 药代动力学, 吸收

Abstract: AIM: To study the pharmacokinetics of compound aluminum sulfate injection after i.v.administration and aluminum absorption after i.m.and s.c. administration in New Zealand rabbits.Methods: Compound aluminum sulfate injection was administrated i.v.to the left-earat the dose of 1 mg·kg^-1, i.m.in quadriceps at the dose of 80 mg·kg^-1 or s.c.under back skin at the dose of 160 mg·kg^-1 (anhydrous aluminum sulfate body weight).Blood samples were collected at different time after injection from the right-ear vein. ICP-MS assay was used to determine the aluminum (Al) concentration.Pharmacokinetic parameters were calculated with DAS program.Results: The blood Al concentration-time profiles after i.v.injection fitted to a twocompartment model, with t_1/2β 1.08±0.46 h and AUC_0-12h1.52±0.92 mg·h·L^-1 (n=5).There was no obvious increase in Al concentration after i.m.injection of 80 mg·kg^-1 or s.c.injection of 160 mg·kg^-1 aluminum sulfate.The average AUC_0-24h of i.m.injection was 2.93±1.82 mg·h·L^-1 (n=5), and that of s.c.injection was 0.88±1.14 mg·h·L^-1 (n=5), corresponding to the bioavailability of i.m.and s.c.injection being about 2.41% and 0.36%, respectively.Conclusion: Blood Al eliminates very quickly.The absorbed Al after i.m.or s.c.injection is very low, suggesting compound aluminum sulfate injection a safe preparation.

Key words: compound aluminum sulfate injection, pharmacokinetics, absorption