1 Okano M, Bell, DW, Haber DA, Li E.DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development[J].Cell, 199;99:247-57
2 Tate PH, Bird AP.Effects of DNA methylation on DNA-binding proteins and gene expression[J].Curr Opin Genet Dev, 199;3:226-31
3 Jones PA, Baylin SB.The fundamental role of epigenetic events in cancer[J].Nat Rev Genet, 2002;3:415-28
4 Lee WH, Morton RA, Epstein JI, Brooks JD, Campbell PA, Bova GS, et al.Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis[J].Proc Natl Acad Sci USA, 1994;9:11733-7
5 Leone G, Teofili L, Voso MT, Lubbert M.DNA methylation and demethylating drugs in myelody splastic syndromes and secondary leukemias[J].Haematologica, 2002;8:1324-41
6 Robertson KD.DNA methylation and human disease[J].Nat Rev Genet, 2005;6:597-610
7 De Ruijter AJM, van Gennip AH, Caron HN, Kemp S, van Kuilenburg ABP.Histone deacetylases (HDACs):characterization of the classical HDAC family[J].Biochem J, 200;370:737-49
8 Metzger E,Wissmann M, Yin N, Muller JM, Schneider R, Peters AH, et al.LSDdemethylates repressive histone marks to promote androgen-receptor-dependent transcription [J].Nature,200;437:436-9
9 Li J, Lin Q, Yoon HG, Huang ZQ, Strahl BD, Allis CD, et al.Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor[J].Mol Cell Biol, 200;22:5688-97
10 Dover J, Schneider J, Tawiah-Boateng MA, Wood A, Dean K,Johnston M, et al.Methylation of histone Hby COMPASS requires ubiquitination of histone H2B by Rad6[J].J Biol Chem,200;277:28368-71
11 Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, ZhouMM.Structure and ligand of a histone acetyl transferase bromodomain[J].Nature , 199;39:491-6
12 Altucci L, Gronemeyer H.The promise of retinoids to fight against cancer[J].Nat Rev Cancer, 2001;1:181-93
13 Zhang Y, Reinberg D.Transcription regulation by histone methylation:interplay between different covalent modifications of the core histone tails[J].Genes Dev, 2001;15:2343-60
14 Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO,Allshire RC, et al.Selective recognition of methylated lysine on histone Hby the HPchromo domain[J].Nature, 2001;410:120-4
15 Sims RJ Ⅲ, Nishioka K, Reinberg D.Histone lysine methylation:a signature for chromatin function[J].Trends in Genetics,2003;1:629-39
16 Jackson JP, Lindroth AM, Cao X, Jacobsen SE.Control of CpNpG DNA methylation by the KRYPTONITE histone Hmethyltransferase[J].Nature, 2002;416:556-60
17 Issa JP, Kantarjian HM, Kirkpatrick P.Azacitidine[J].Nature Reviews Drug Discovery, 2005;4:275-6
18 Cheng JC,Weisenberger DJ, Gonzales FA, Liang G, Xu GL, Hu YG, et al.Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells[J].Mol Cell Biol,2004;2:1270-8
19 Zambrano P, Segura-Pacheco B, Perez-Cardenas E, Cetina L,Revilla-Vazquez A, Taja-Chayeb L, et al.A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes[J].BMC Cancer, 2005;5:44
20 Segura-Pacheco B, Trejo-Becerril C, Perez-Cardenas E, Taja-Chayeb L, Mariscal I, Chavez A, et al.Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy[J].Clin Cancer Res, 2003;9:1596-603
21 Yao XM, Hu JF, Daniels M, Shiran H, Zhou X, Yan H, et al.A methylated oligonucleotide inhibits IGFexpression and enhances survival in a model of hepatocellular carcinoma[J].J Clin Inv , 2003;111:265-73
22 Ishii T, Fujishiro M,Masuda M, Teramoto S, Matsuse T.A methylated oligonucleotide induced methylation of GSTPpromoter and suppressed its expression in A54lung adenocarcinoma cells[J].Cancer Lett, 2004;212:211-23 |
