关键词: 缬沙坦, 高血压, 昼夜节律, 醛固酮

Abstract: AIM: To investigate the circadian variability of the dipper blood pressure induced by valsartan in patients with non-dipper essential hypertension, and to observe levels of aldosterone. METHODS: The patients were divided into dipper and non-dipper groups.All patients were treated with valsartan (160 mg/d).The variability of circadian blood pressure were observed, and the levels of plasma aldosterone were monitored, too. RESULTS: After the treatment with valsartan, the systolic and diatolic blood pressure in all patients, either dipper or non-dipper groups, were evidently reduced, especially, the patient with non-dipper essential hypertension had more significant improvement.The circadian variability was appeared.The levels of aldosterone had a significant difference. CONCLUSION: Valsartan has significant effects for the patients with non-dipper essential hypertension.It can induce a circadian variability and recover the dipper blood pressure from non-dipper blood pressure.

Key words: valsartan, essential hypertension, ambulatory, aldosterone