慢性非细菌性前列腺炎动物模型研究进展

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (1): 14-18.

慢性非细菌性前列腺炎动物模型研究进展

钱伯初^1,2, 史红¹, 郑晓亮¹

¹浙江省医学科学院药物研究所, 杭州 310013, 浙江;
²浙江大学城市学院药物研究所, 杭州 310015, 浙江

收稿日期:2006-09-25 修回日期:2006-10-14 出版日期:2007-01-26 发布日期:2020-10-26
作者简介:钱伯初, 男, 研究员, 硕士生导师, 主要从事中药药理与新药研发。Tel:0571-88215627 13958114545 　E-mail: qianbochu@yahoo.com.cn

Progress in research on animal models of chronic nonbacterial prostatitis

QIAN Bo-chu^1,2, SHI Hong¹, ZHENG Xiao-liang¹

¹Institute of Materia Medica, Zhejiang Academy of Medical Science, Hangzhou 310013, Zhejiang, China;
²Institute of Materia Medica, Zhejiang University City College, Hangzhou 310015, Zhejiang, China

Received:2006-09-25 Revised:2006-10-14 Online:2007-01-26 Published:2020-10-26

摘要/Abstract

摘要： 慢性非细菌性前列腺炎是一种病因和发病机理未明、难于诊治的泌尿科常见病。研究制备的动物模型是阐明该病发病机理和开发新药的有效方法。因此, 用作研究人类疾病的动物模型的有效性是选择动物模型最重要的标准, 由于不同动物模型的不同特点, 实验时应适当选择。本文就近年来慢性非细菌性前列腺炎动物模型的相关研究作简要综述。

关键词: 慢性非细菌性前列腺炎, 动物模型, 自身免疫, 部分尿道阻塞, 雌二醇, 角叉菜胶, 消痔灵注射液, 大鼠

Abstract: Chronic nonbacterial prostatitis is a common urologic condition which is difficult to be treated effectively. Little is known about the etiology and pathogenesis of the disease. Preparation of the animal model of chronic nonbacterial prostatitis is an effective method to research the pathogenesis of the disease and development of new drug. Different animal models have distinctive traits, therefore, it is crucial to select suitable animal models for researching human diseases. In the review, the progress in the research on animal models of such disease is discussed.

Key words: chronic nonbacterial prostatitis, animal model, autoimmune, partial urethral obstruction, rat, estradiol, carrageen

中图分类号:

R965.1

钱伯初, 史红, 郑晓亮. 慢性非细菌性前列腺炎动物模型研究进展[J]. 中国临床药理学与治疗学, 2007, 12(1): 14-18.

QIAN Bo-chu, SHI Hong, ZHENG Xiao-liang. Progress in research on animal models of chronic nonbacterial prostatitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(1): 14-18.

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