β-肾上腺素受体遗传多态性与疾病易感性及药物反应差异的关系

摘要/Abstract

摘要： β-肾上腺素受体是G 蛋白偶联受体的一个亚家族, 它们以儿茶酚胺为内源性配体, 介导机体的重要生理功能;同时, β-肾上腺素受体也是许多药物的作用靶点。本文重点阐述β-肾上腺素受体常见的遗传多态性与疾病易感性及药物反应差异的关系。

关键词: β-肾上腺素受体, 遗传多态性, 药物反应

Abstract: β-adrenergic receptor is one subfamily belongs to G-protein coupled receptor, which modulates various physiologic functions in response to endogenous catecholamines and acts as a target for many drugs. This article elucidates mainly the relationship between β-adrenergic receptor genetic polymorphism and disease susceptibility as well as differences in drug response.

Key words: β-adrenergic receptor, genetic polymorphism, drug response

中图分类号:

R969

刘洁, 刘昭前, 周宏灏. β-肾上腺素受体遗传多态性与疾病易感性及药物反应差异的关系[J]. 中国临床药理学与治疗学, 2007, 12(6): 601-608.

LIU Jie, LIU Zhao-qian, ZHOU Hong-hao. Relationship between β-adrenergic receptor genetic polymorphism and disease susceptibility as well as differences in drug response[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(6): 601-608.

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