左旋卡尼汀治疗慢性肺心病急性加重期患者疗效观察

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (11): 1295-1297.

左旋卡尼汀治疗慢性肺心病急性加重期患者疗效观察

闫培清, 卜宪聪, 葛长胜, 冯辉, 张华, 于晓红

山东省日照市中医医呼吸内科, 日照 276800, 山东

收稿日期:2008-09-09 修回日期:2008-11-11 出版日期:2008-11-26 发布日期:2020-10-14
作者简介:闫培清, 男, 本科, 副主任医师。Tel:13906330468 E-mail: bdfh12@163.com

Effects of levocarnitine in treating patients with acute exacerbation of chronic pulmonary heart disease

YAN Pei-qing, BU Xian-cong, GE Chang-sheng, FENG Hui, ZHANG Hua, YU Xiao-hong

Rizhao Traditional Chinese Medicine Hospital, Rizhao 276800, Shandong, China

Received:2008-09-09 Revised:2008-11-11 Online:2008-11-26 Published:2020-10-14

摘要/Abstract

摘要： 目的: 评价左旋卡尼汀对慢性肺心病急性加重期患者的疗效。方法: 126 例随机分成两组。对照组60 例, 用吸氧、抗感染、祛痰、平喘、利尿等常规治疗;治疗组66 例, 在常规治疗基础上加用左旋卡尼汀3.0 静脉点滴, 每日1 次, 14 d 为一疗程。结果: 治疗组临床总有效率(89.4 %) 明显优于对照组(65.0 %) (P <0.01) ;两组动脉血气、心脏指数、射血分数及右室内径均显著改善(P <0.01), 治疗组改善更为显著(P <0.01) 。结论: 左旋卡尼汀治疗慢性肺心病急性加重期患者是有效的。

关键词: 左旋卡尼汀, 肺心病, 急性加重

Abstract: AIM: To evaluate the efficacy of levocarnitine in treating patients with acute exacerbation of chronic pulmonary heart disease. METHODS: 126 patients were divided into two groups randomly: 60 patients in control group were treated with conventional therapy for inhalling oxygen, controlling infection, relieving asthma, expelling phlegm and diuresis ;66 patients in test group were treated with 3 g /d levocarnitine, i.v. drip for 14 days in addition to conventional therapy. RESULTS: The total effective rate in test group was superior to that of control group(P <0.01). The arterial blood gases, cardiac index, ejection fraction and right ventricular internal diameter were improved significantly(P <0.01) in two groups. The test group was remarkably improved compared with control group after treatment (P <0.01). CONCLUSION: Levocarnitine is effective in treating patients with acute exacerbation of chronic pulmonary heart disease.

Key words: levocarnitine, pulmonary heart disease, acute exacerbation

中图分类号:

R563

闫培清, 卜宪聪, 葛长胜, 冯辉, 张华, 于晓红. 左旋卡尼汀治疗慢性肺心病急性加重期患者疗效观察[J]. 中国临床药理学与治疗学, 2008, 13(11): 1295-1297.

YAN Pei-qing, BU Xian-cong, GE Chang-sheng, FENG Hui, ZHANG Hua, YU Xiao-hong. Effects of levocarnitine in treating patients with acute exacerbation of chronic pulmonary heart disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(11): 1295-1297.

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