CYP2B6 基因多态性及其功能意义的研究进展

摘要/Abstract

摘要： CYP2B6 是一个在药理和毒理学上均占有重要地位的代谢酶, 参与约7 %临床上常用药物代谢, 其中包括一些治疗窗较窄的药物。CYP2B6具有高度基因多态性, 在基因编码区和非编码存在许多单碱基突变。到目前为止, 已发现并被命名的等位基因有CYP2B6^*1 ~^*29。本文主要对CYP2B6 的基因多态性、种族差异及其在药物代谢上的功能意义等方面的研究进展进行综述。

关键词: CYP2B6, 基因多态性, 药物代谢

Abstract: CYP2B6 is an important cytochrome P450 enzymes and contributes to metabolism of about 7 % of therapeutically usual drugs, including somewith narrow therapeutic index.The human CYP2B6 gene is highly polymorphic, having many single nucleotide polymorphisms in promoters and coding regions.To date, at least 29 CYP2B6 alleles have been identified. This review summarizes recent advances in the study of CYP2B6 about gene polymorphism, the frequency of CYP2B6 alleles among different populations, and their clincal significance.

Key words: CYP2B6, gene polymorphism, drug Metabolism

中图分类号:

R969

覃文杰, 周宏灏. CYP2B6 基因多态性及其功能意义的研究进展[J]. 中国临床药理学与治疗学, 2008, 13(12): 1434-1440.

QIN Wen-jie, ZHOU Hong-hao. Advances in study of CYP2B6 gene polymorphisms and its functional significances[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(12): 1434-1440.

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