河鲀Ⅰ型胶原蛋白提取物防治环磷酰胺、顺铂或阿糖胞苷诱发小鼠骨髓抑制的研究

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (2): 201-207.

河鲀Ⅰ型胶原蛋白提取物防治环磷酰胺、顺铂或阿糖胞苷诱发小鼠骨髓抑制的研究

李胜前¹, 陈丁丁¹, 高利忠²

¹中国药科大学药理研究室, 南京 210009, 江苏;
²南京宝生药业有限公司, 南京 210036, 江苏

收稿日期:2007-04-13 修回日期:2007-06-20 出版日期:2008-02-26 发布日期:2020-10-14
通讯作者: 陈丁丁, 男, 副教授, 硕士生导师, 研究方向:生化药理和临床药学。Tel:025-83271264 　E-mail:besson@besson.com.cn
作者简介:李胜前, 男, 硕士研究生, 研究方向:临床药学。Tel:13675155142 E-mail:lsqian50105@sohu.com

Pufferfish type Ⅰ collagen extract prevented and cured myelosuppression induced by cyclophosphamide or diamminedichloroplatinum or cytosine arabinoside in mice

LI Sheng-qian¹, CHEN Ding-ding¹, GAO Li-zhong²

¹Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China;
²Nanjing Besson Pharmaceuticals Co., Ltd., Nanjing 210036, Jiangsu, China

Received:2007-04-13 Revised:2007-06-20 Online:2008-02-26 Published:2020-10-14

摘要/Abstract

摘要： 目的:观察河Ⅰ 型胶原蛋白提取物(Pufferfish type Ⅰ collagen extract, PTICE) 对环磷酰胺(CTX) 、顺铂(DDP) 或阿糖胞苷(Ara-c) 诱发的小鼠骨髓抑制的影响。方法:分别用CTX 、DDP 、Arac腹腔注射(i.p.) 诱发小鼠骨髓抑制、免疫抑制等毒副反应, PTICE 灌胃(i.g.) 预防治疗, 观察小鼠的一般状况, 测定外周血细胞分类、脾脏指数和骨髓DNA 含量。结果:PTICE 可改善应用上述化疗药物小鼠的一般状况, 保护小鼠毛发, 升高外周血中的白细胞、血小板、中性粒细胞、淋巴细胞数,增加脾脏指数和骨髓DNA 含量;PTICE 显著降低DDP 导致的小鼠死亡率。结论:PTICE 可降低化疗药物引起的小鼠骨髓抑制等毒副作用。

关键词: 河鲀Ⅰ 型胶原蛋白提取物, 环磷酰胺, 顺铂, 阿糖胞苷, 骨髓抑制

Abstract: AIM:To observe the effects of Pufferfish type Ⅰ collagen extract (PTICE) on mouse toxic and adverse reactions induced by cyclophosphamide (CTX) or diamminedichloroplatinum (DDP) or cytosine arabinoside (Ara-c). METHODS:Mouse myelosuppression model was induced by i. p. CTX or DDP or Ara-c, i. g. PTICE to prevent and cure. The mental status, level of body weight and pelage were observed. The peripheral hemogram, spleen index, and contents of bone marrow DNA were determined. RESULTS:PTICE could obviously improve the mental status, protect the pelage, raise the counts of white blood cell, platelet, neutrophil, lymphocyte and increase the spleen index and contents of bone marrow DNA. PTICE decreased the mice mortality rate induced by DDP. CONCLUSION:PTICE could reduce myelosuppression induced by cyclophosphamide or diamminedichloroplatinum or cytosine arabinoside in mice.

Key words: Pufferfish type Ⅰ collagen extract, cyclophosphamide, diamminedichloroplatinum, cytosine arabinoside, myelosuppression

中图分类号:

R965.2

李胜前, 陈丁丁, 高利忠. 河鲀Ⅰ型胶原蛋白提取物防治环磷酰胺、顺铂或阿糖胞苷诱发小鼠骨髓抑制的研究[J]. 中国临床药理学与治疗学, 2008, 13(2): 201-207.

LI Sheng-qian, CHEN Ding-ding, GAO Li-zhong. Pufferfish type Ⅰ collagen extract prevented and cured myelosuppression induced by cyclophosphamide or diamminedichloroplatinum or cytosine arabinoside in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 201-207.

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