槲皮素对非细菌性前列腺炎治疗作用的实验研究

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (6): 648-653.

槲皮素对非细菌性前列腺炎治疗作用的实验研究

程丽艳, 郑晓亮, 史红

浙江省医学科学院药物所, 杭州 310013, 浙江

收稿日期:2008-03-25 修回日期:2008-05-15 发布日期:2020-10-14
通讯作者: 史红,女,研究员,硕士生导师,从事中药药理学研究及新药研发。Tel:0571-88215621 E-mail:shihong_86@yahoo.com.cn
作者简介:程丽艳,女,硕士,研究实习员,研究方向:神经药理学。Tel:0571-88215621 E-mail:ziding6374@163.com
基金资助:
浙江省中医药科研基金计划项目(2006C039)

Experimental study on therapeutic effects of quercetin on abacterial prostatitis

CHENG Li-yan, ZHENG Xiao-liang, SHI Hong

Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China

Received:2008-03-25 Revised:2008-05-15 Published:2020-10-14

摘要/Abstract

摘要： 目的: 观察槲皮素对实验性非细菌性前列腺炎的治疗效果。方法: 采用五种模型、包括消痔灵诱导的大鼠慢性前列腺炎模型、角叉菜胶诱导的急性前列腺炎模型、巴豆油致耳肿胀模型、光刺激致痛模型、棉球肉芽肿模型及体外测定离体家兔尿道平滑肌张力试验,观察槲皮素的作用。结果: 槲皮素对大鼠急慢性非细菌性前列腺炎具有良好的抗炎作用,对耳肿胀试验、肉芽肿试验及光刺激致痛试验具有良好的抑制作用,并对离体的尿道平滑肌具有较好的舒张作用。结论: 槲皮素对实验性非细菌性前列腺炎具有良好的抑制作用,并对尿道平滑肌具有一定舒张作用,提示槲皮素具有良好的临床治疗非细菌性前列腺炎作用,并能缓解排尿困难症状。

关键词: 槲皮素, 前列腺炎, 治疗

Abstract: AIM: To study the anti-inflammatory effects of quercetin on the experimental animal models of abacterial prostatitis.METHODS: Five types of experimental animal inflammatory models in vivo were applied to investigate the anti-inflammatory and analgesic effects of quercetin, including xiaozhiling-induced chronic prostatitis, carrageenan-induced acute prostatitis, croton oil-induced auricle swelling, photothermal stimulation-induced pain, cotton ball granuloma test of mice, and the rabbit urethral smooth muscle tensile test in vitro to examine the catabatic effects on dysuria.RESULTS: Quercetin displayed good anti-inflammatory effects on acute and chronic abacterial prostatitis. Quercetin also had good inhibitory effects on croton oilinduced auricle swelling, photothermal stimulation-induced pain and cotton ball granuloma test of mice and had definite relaxing effects on rabbit urethral smooth muscle.CONCLUSION: It indicates that quercetin has good therapeutic effects on abacterial prostatitis and could alleviate dysuria.

Key words: quercetin, prostatitis, therapeutic

中图分类号:

R965.2

程丽艳, 郑晓亮, 史红. 槲皮素对非细菌性前列腺炎治疗作用的实验研究[J]. 中国临床药理学与治疗学, 2008, 13(6): 648-653.

CHENG Li-yan, ZHENG Xiao-liang, SHI Hong. Experimental study on therapeutic effects of quercetin on abacterial prostatitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(6): 648-653.

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