壳聚糖衍生物在抗肿瘤方面的研究进展

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (8): 952-956.

壳聚糖衍生物在抗肿瘤方面的研究进展

王晓霁¹, 杨靖亚¹, 刘建文²

¹上海海洋大学食品学院, 上海200090;
²华东理工大学药学院, 上海200237

收稿日期:2008-06-06 修回日期:2008-07-27 出版日期:2008-08-26 发布日期:2020-10-12
通讯作者: 杨靖亚, 女, 博士, 副教授, 硕导, 主要从事海洋生物资源综合利用与海洋药物的开发、肿瘤药理学的研究。Tel:021-65711476　E-mail:jyyang@shou.edu.cn
作者简介:王晓霁, 女, 硕士研究生在读, 主要从事海洋生物资源综合利用与海洋药物的开发、肿瘤药理学的研究。Tel:13917704243　E-mail:gigibaby228@163.com
基金资助:
上海市重点学科建设项目(T1102)

Research progress of chitosan derivatives in antitumor studies

WANG Xiao-ji¹, YANG Jing-ya¹, LIU Jian-wen²

¹College of Food Science and Technology, Shanghai Ocean University, Shanghai 200090, China;
²College of Pharmaceutical Sciences, East China University of Science and Technology, Shanghai 200237, China

Received:2008-06-06 Revised:2008-07-27 Online:2008-08-26 Published:2020-10-12

摘要/Abstract

摘要： 随着科学理论和实践研究的进展, 壳聚糖衍生物在抗肿瘤方面应用有所突破。壳聚糖衍生物因其稳定性、生物相容性、生物可降解性、低毒性、体内长期保留性等优点, 显示出了良好的研究前景。本文综述了壳聚糖衍生物抗肿瘤性质、作为药物载体应用以及对物理治疗辅助作用。这些资料都说明了壳聚糖衍生物在抑制肿瘤生长和延长存活期方面起到了积极作用。

关键词: 壳聚糖衍生物, 抗肿瘤, 载体

Abstract: Application of chitosan derivatives in antitumor studies had gained great progress with the development of theory and practice, which exhibited good prospect for its favourable properties, such as stability, biocompatibility, biodegradability, low toxicity and long-term retention in the body.Antitumor properties of chitosan derivatives, application of chitosan derivatives as drug carrier and auxiliary function of physical therapy were concluded in this review.The data showed that chitosan derivatives played an active role in suppression of tumour growth and prolongation of survival period.

Key words: chitosan derivatives, antitumor, carrier

中图分类号:

R969

王晓霁, 杨靖亚, 刘建文. 壳聚糖衍生物在抗肿瘤方面的研究进展[J]. 中国临床药理学与治疗学, 2008, 13(8): 952-956.

WANG Xiao-ji, YANG Jing-ya, LIU Jian-wen. Research progress of chitosan derivatives in antitumor studies[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(8): 952-956.

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