地塞米松诱导产生耐受性树突状细胞的机制

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (1): 113-116.

地塞米松诱导产生耐受性树突状细胞的机制

何小魁, 胡永秀

首都医科大学免疫学系, 北京 100069

收稿日期:2008-08-07 修回日期:2008-12-18 出版日期:2009-01-26 发布日期:2020-10-27
通讯作者: 胡永秀,女, 教授, 硕士生导师, 研究方向:移植免疫。Tel:010-83911742 E-mail:yxh601 @bj163.com
作者简介:何小魁, 女, 硕士研究生, 研究方向:移植免疫。Tel:010-83911438 　E-mail:xiaohe198111@126.com
基金资助:
北京市教委科技发展计划资助项目(KM200710025005)

Mechanisms of Dexamethasone inducing generation of tolerogenic dendritic cells

HE Xiao-kui, HU Yong-xiu

Immunology Section of Capital Medical University, Beijing 100069, China

Received:2008-08-07 Revised:2008-12-18 Online:2009-01-26 Published:2020-10-27

摘要/Abstract

摘要： 糖皮质激素地塞米松是临床广泛应用的一类免疫抑制剂。近年来研究发现, 在免疫应答反应的早期, 地塞米松是通过影响体内的树突状细胞(dendritic cell,DC)而发挥作用的。地塞米松可通过抑制DC 的分化和成熟、改变DC 的表型和DC 的某些重要生物学功能, 抑制特异性免疫应答反应的启动并减少炎性细胞因子的产生。利用地塞米松对DC 的影响来治疗自身免疫病、肿瘤、移植排斥反应等疾病可能会成为基础和临床医学研究的新热点。

关键词: 地塞米松, 树突状细胞, 免疫耐受

Abstract: Dexamethasone belongs to Glucocorticoids and is one kind of widely used immunosuppressive agents in clinical practice.Recent researches have found that in the early stage of immue responses, Dexamethasone works by affecting dendritic cells in vivo. Dexamethasone can restrain specific immune response priming and reduce inflammatory factor releasing by inhibiting differentiation and maturation of dendritic cells, changing phenotype and some important biological functions of dendritic cells.It has become a new focus in basic and clinical medicine to apply Dexamethasone in treatment of autoimmune diseases, tumor, graft rejection reaction and other diseases through its influence on dendritic cells.

Key words: Dexamethasone, dendritic cell, immune tolerance

中图分类号:

R392

何小魁, 胡永秀. 地塞米松诱导产生耐受性树突状细胞的机制[J]. 中国临床药理学与治疗学, 2009, 14(1): 113-116.

HE Xiao-kui, HU Yong-xiu. Mechanisms of Dexamethasone inducing generation of tolerogenic dendritic cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(1): 113-116.

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