植物药与化学药相互作用研究现状及发展趋势

摘要/Abstract

摘要： 植物药即由植物提取精制而得的天然药物, 多来源于俗称本草的中药。近年来, 植物药与化学药联合应用日益增多, 引起诸多药物相互作用和不良反应。与其攸关重要的环节是人体内细胞色素P450 和ABC 转运体家族参与的药物四大转运过程, 因此研究其作用机制对降低相互作用发生率及指导临床安全合理用药具有十分重要的意义。本文就临床常见植物药与化学药相互作用及其研究现状作一综述, 旨在为同行研究提供参考。

关键词: 植物药, 化学药, P 糖蛋白, CYP450, 药物相互作用

Abstract: Herbs are naturally occurring drugs which were extracted from plants, generally, they come from traditional Chinese medicine.Recently, there are a drastic growth in the combination use of herbs and chemical medicines, which leads to a large number of drug interactions and adverse effects.The CYP450 enzymes and some ABC transporters in human body play an important role in these interactions.Further and deeper researches in this field would be necessary and important to decrease such interactions and guide the safe and rational use in clinic.The paper introduces the drug interactions and latest study progress of common herbs and chemical medicines, it will offer a reference for the research.

Key words: herb, chemical medicine, p-glycoprotein, CYP450, drug interaction

中图分类号:

R969.2

刘志锋, 周宏灏. 植物药与化学药相互作用研究现状及发展趋势[J]. 中国临床药理学与治疗学, 2009, 14(2): 214-219.

LIU Zhi-feng, ZHOU Hong-hao. Research status quo and development of herbs and chemical medicines interactions[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(2): 214-219.

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