降糖复方对亚急性衰老模型小鼠的抗氧化作用

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (3): 283-286.

降糖复方对亚急性衰老模型小鼠的抗氧化作用

章娟, 巫冠中

中国药科大学药理教研室, 南京210009, 江苏

收稿日期:2009-02-13 修回日期:2009-02-13 发布日期:2020-10-27
作者简介:章娟, 女, 硕士研究生在读, 研究方向:内分泌药理。Tel:13776601364 E-mail:zhangjuan1006 @yahoo.com.cn
基金资助:
科技部创新基金(06C26223200246)

Anti-oxidative effect of Jiangtang compound recipe on subacute agingmodel mice

ZHANG Juan, WU Guan-zhong

Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China

Received:2009-02-13 Revised:2009-02-13 Published:2020-10-27

摘要/Abstract

摘要： 目的研究由葛根、鱼腥草、鬼箭羽三味中药组成的复方对D-半乳糖诱导的衰老模型小鼠的抗氧化作用。方法采用D-半乳糖诱导小鼠衰老模型, 以其体重变化、血清与组织中丙二醛(MDA) 含量、超氧化物歧化酶(SOD) 与谷胱甘肽过氧物酶(GSH-Px) 活力为指标, 考察药物对衰老小鼠的抗氧化作用。结果降糖复方(14 、7 g kg,i.g.) 能对抗D-半乳糖所致衰老模型小鼠血清与组织中MDA 含量的升高, 提高其中SOD 与GSHPx活力, 并能抑制小鼠体重的下降。结论降糖复方能有效地对抗D-半乳糖所致小鼠的氧化损伤, 具有一定的抗氧化作用。

关键词: 降糖复方, D-半乳糖, 丙二醛, 超氧化物歧化酶, 谷胱甘肽过氧物酶

Abstract: AIM: To study the effect of antioxidation in subacute aging model mice with Jiangtang compound recipe which composed of kudzuvine root, heartleaf houttuynia herb and Evonymus alatas. METHODS: By using the D-galactose-induced aging mice, the body weight, the content of malondialdehyde (MDA), the activities of superoxide dismutarse(SOD) and glutothine peroxidase (GSH-Px) in serum and tissues were determined. RESULTS: To the model mice, Jiangtang compound recipe (14, 7 g kg, i.g.) reduced the content of MDA, enhanced the activities of SOD and GSH-Px in serum and tissuses, inhibited the decrease of body weight. CONCLUSION: Jiangtang compound recipe shows a remarkable anti-oxidative effect on the D-galactose-induced aging mice.

Key words: Jiangtang compound recipe, D-galactose, malondialdehyde, superoxide dismutarse, glutathione peroxidase

中图分类号:

R965.2

章娟, 巫冠中. 降糖复方对亚急性衰老模型小鼠的抗氧化作用[J]. 中国临床药理学与治疗学, 2009, 14(3): 283-286.

ZHANG Juan, WU Guan-zhong. Anti-oxidative effect of Jiangtang compound recipe on subacute agingmodel mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(3): 283-286.

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