何首乌颗粒治疗2 型糖尿病高脂血症疗效观察

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (4): 443-447.

何首乌颗粒治疗2 型糖尿病高脂血症疗效观察

丁平¹, 竹剑平²

¹浙江省义乌市第二医院, 义乌322000, 浙江;
²浙江省中医药研究院, 杭州310007, 浙江

收稿日期:2009-02-26 修回日期:2009-05-05 发布日期:2020-10-29
作者简介:丁平,男,研究方向:中医临床。 E-mail:zjlcyx@163.com

Study on the clinical therapeutic effect of Heshouwu granula on type 2 diabetic hyperlipemia

DING Ping¹, ZHU Jian-ping²

¹The Second Hospital of Yiwu, Yiwu 322000, Zhejiang, China;
²Chinese Medicine Research Institute of Zhejiang Province, Hangzhou 310007, Zhejiang, China

Received:2009-02-26 Revised:2009-05-05 Published:2020-10-29

摘要/Abstract

摘要： 目的: 观察何首乌颗粒对2 型糖尿病高脂血症的临床疗效。方法: 对106 例2 型糖尿病高脂血症患者,按血糖、血脂水平、性别、年龄、病程、服药种类等随机分为试验组52 例与对照组54例。两组患者继续服用原降糖药及糖尿病运动饮食控制。试验组服用何首乌颗粒,每日3 次,每次1 袋,每袋3 g 。对照组服用辛伐他汀10 mg,每日1 次。两组均连续服用45 d 。结果: 试验组临床症状有明显改善,症状积分明显降低,与试验前比较差异有统计学意义(P<0.05),与对照组比较差异也有统计学意义(P<0.01);试验组空腹血糖有所下降,与试验前比较差异有统计学意义(P<0.01),与对照组比较差异均有统计学意义(P<0.05,P<0.01);试验组餐后2 h 血糖有所下降,下降幅度与对照组比较差异有统计学意义(P<0.05);试验组尿糖与试验前比较差异有统计学意义(P<0.05);试验组TC、TG 与试验前比较差异有统计学意义(P<0.05),但与对照组比较差异无统计学意义(P>0.05);试验组显效12 例,有效29 例,总有效率为78.85 %,与对照组比较差异有统计学意义(P<0.05)。结论: 何首乌颗粒治疗2 型糖尿病型高血脂症有一定疗效,且优于辛伐他汀。

关键词: 何首乌颗粒, 2 型糖尿病高脂血症, 临床疗效

Abstract: AIM: To evaluate the clinical therapeutic effect of Heshouwu granula on type 2 diabetic hyperlipemia.METHODS: 106 cases with type 2 diabetic hyperlipemia were divided into two groups :52 in test group and 54 in control group.In addition of their conventional treatment of hypoglycemic agents and diabetic diet and exercise, Heshouwu granulas were used in test group, the dosage was 3 g (one pouch) once per day.Simvastatin of 10 mg once per day was used in control group.Both groups were treated for consecutive 45 days.RESULTS: The symptoms in test group were improved, the scores of the symptoms were lowered significantly compared with both that before treatment (P<0.05) and that of compare group (P<0.01) ;in test group, the blood glucose was significantly lowered compared with that before treatment and that in control group(P<0.05, P<0.01).The 2-hour postprandial glucose in control group was decreased significantly compared with that in control group(P<0.05).The urine glucose was decreased significantly than that before treatment (P<0.05).The cholesterol and triglyceride in test group were decreased significantly compared with those before treatment (P<0.05) but not significantly compared with those in control group(P>0.05).There were 12 cases with market effect and 29 with effectiveness in test group, the total effective rate was 78.85 %, which was significantly effective than that in control group(P<0.05).CONCLUSION: Heshouwu granula is effective for treating type 2 diabetic hyperlipemia, and the efficiacy is better than simvastatin.

Key words: Heshouwu granula, type 2 diabetic hyperlipemia, clinical therapeutic effect

中图分类号:

R587.2

丁平, 竹剑平. 何首乌颗粒治疗2 型糖尿病高脂血症疗效观察[J]. 中国临床药理学与治疗学, 2009, 14(4): 443-447.

DING Ping, ZHU Jian-ping. Study on the clinical therapeutic effect of Heshouwu granula on type 2 diabetic hyperlipemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 443-447.

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