关键词: 进展期胃癌, 顺铂, 药代动力学

Abstract: AIM:To compare the characteristics of cisplatin pharmacokinetics: preoperative intraperitoneal administration versus intravenous chemotherapy with cisplatin for advanced gastric carcinoma. METHODS: 50 patients with resectable advanced gastric cancer were randomly divided into 2 groups: 26 cases with preoperative intraperitoneal administration of cisplatin (i. p. group)and 24 cases with preoperative intravenous administration of cisplatin (i. v. group).Each patient was given 60 mg/m² cisplatin intraperitoneally or intravenously. The peritoneal fluid, blood from gastric sinistral vein and peripheral blood were taken on the 180th minutes after the drug was administrated. Cancer tissues and normal tissues beside the cancer tissue were collected at the 270th minutes during operation. Another 8 cases were used to study the pharmacokinetics of intraperitoneal administration and intravenous chemotherapy with cisplatin. The concentrations of cisplatin in different samples were measured by the flameless type of atomic absorption spectrometry. RESULTS: The high cisplatin concentration in abdominal cavity could maintain for fairly longer time by intraperitoneal administration more than by intravenous administration. And the plasma concentrations of cisplatin in peritoneal cavity were similar by the two injection styles. The AUC with intraperitoneal administration was about five times than that with intravenous administration. The cisplatin concentrations of peritoneal fluid and vena gastrica sinistra blood in the i. p. group were 23. 4 and 2. 53 times higher than those in the i. v. group respectively (P <0. 01).The cisplatin of the cancer tissue in the i. p. group was higher than that in the i. v. group(P <0. 05).CONCLUSION:The intraperitioneal cisplatin chemotherapy has better pharmacokinetics parameters and could be a useful accessory treatment for the advanced gastric carcinoma cancer.

Key words: advanced gastric carcinoma, cisplatin, pharmacokinetics