药物治疗蛛网膜下腔出血后迟发性脑血管痉挛研究进展

摘要/Abstract

摘要： 迟发性脑血管痉挛(delayed cerebral vaso-spasm, DCVS) 是蛛网膜下腔出血 (subarachnoidhemorrhage, SAH) 患者致死致残的重要原因, 但其病理生理过程仍不明确。对治疗 DCVS 有效的药物显得尤为重要, 包括离子通道阻断剂或开放剂,内皮素(ET) 合成抑制剂及其受体拮抗剂, 抗炎、抗氧化制剂, 纤维蛋白溶解剂和祖国传统医药等。本文综述近年来对SAH 后 DCVS 的基础和临床药物治疗研究进展, 探讨各种药物的使用、疗效以及目前存在的争议。

关键词: 蛛网膜下腔出血, 迟发性脑血管痉挛, 药物治疗

Abstract: Delayed cerebral vasospasm (DCVS) is an important incapacitating or lethal cause after sub-arachnoid hemorrhage (SAH) , but the patho-physiolog-ical process was vague .The effective drugs of treating DCVS are particularly important including ion channel blockers or openers, endothelin synthetic inhibitor or receptor antagonist, anti-inflammatory agents, antioxi-dants, fibrinolytic agents, traditional Chinese herbs, etc. The article reviews the research progress in the preclin-ical and clinical pharmacotherapy on DCVS after SAH, and explores the applications and effects and debates about these therapeutic drugs at present .

Key words: subarachnoid hemorrhage, delayed cerebral vasospasm, pharmacotherapy

中图分类号:

R453
R743.35

熊方令, 高宜录. 药物治疗蛛网膜下腔出血后迟发性脑血管痉挛研究进展[J]. 中国临床药理学与治疗学, 2009, 14(8): 955-960.

XIONG Fang-ling, GAO Yi-lu. Research progress of pharmacotherapy on delayed cerebral vasospasm after subarachnoid hemorrhage[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(8): 955-960.

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