基于RBL-2H3细胞模型的I型过敏反应和类过敏反应研究

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (11): 1310-1314.

基于RBL-2H3细胞模型的I型过敏反应和类过敏反应研究

赵吟, 李钦, 张信岳

浙江省医学科学院药物研究所,杭州 310013,浙江

收稿日期:2010-11-04 修回日期:2010-11-13 出版日期:2010-11-26 发布日期:2020-09-16
通讯作者: 张信岳,副研究员,硕士生导师,研究方向:新药临床前药理学评价及中药注射剂不良反应机制研究。Tel: 0571-88215600 E-mail: zhangxy2003@yahoo.cn
作者简介:赵吟,女,硕士研究生,研究方向:新药临床前药理学评价及中药注射剂不良反应机制研究。Tel: 0571-88215600 E-mail: emilyin0922@hotmail.com
基金资助:
浙江省自然科学基金(Y206846);浙江省科技厅面上项目(2009C33033)资助

Study progress of type I anaphylaxis reaction and anaphylactoid reaction on the basis of RBL-2H3 cell models

ZHAO Yin, LI Qin, ZHANG Xin-yue

Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang,China

Received:2010-11-04 Revised:2010-11-13 Online:2010-11-26 Published:2020-09-16

摘要/Abstract

摘要： I型速发型过敏是常见的药物不良反应,长期受到人们的广泛重视和研究。类过敏反应自20世纪80年代在造影剂和麻醉剂的使用中发现以来,其发生频率不断提高,尤其随着中药注射剂的广泛使用而越来越受到重视。但其确切机理还尚未得到阐明。RBL-2H3细胞是一类表面含有丰富的IgE受体鼠嗜碱性淋巴细胞,在研究过敏反应方面有重要作用。本文就如何以RBL-2H3细胞构建这两类过敏反应的体外细胞模型及如何检测其效应分子进行简单阐述,同时介绍这两类反应机制的研究进展。

关键词: RBL-2H3 细胞模型, 超敏反应, 类过敏反应, 药物筛选, 分子机制

Abstract: It have been apparently considerable research work on type I anaphylaxis reaction since it was discovered in early 20th.Anaphylactoid reaction was first described in application of anaesthetic and contrast medium in 1980s.With the ascending rate of anaphylactoid responses accompanied the increasing use of traditional Chinese medicine injections, much attention has been paid to this field in order to clarify the mechanism.This article focuses on the cell model of type I and pseudoallergic reaction based on RBL-2H3 cell with the latest detection methods and molecular mechanism in vitro.

Key words: RBL-2H3 cell model, Anaphylaxis reaction, Anaphylactoid reaction, Drug screening, Molecular mechanism

中图分类号:

R392.8

赵吟, 李钦, 张信岳. 基于RBL-2H3细胞模型的I型过敏反应和类过敏反应研究[J]. 中国临床药理学与治疗学, 2010, 15(11): 1310-1314.

ZHAO Yin, LI Qin, ZHANG Xin-yue. Study progress of type I anaphylaxis reaction and anaphylactoid reaction on the basis of RBL-2H3 cell models[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(11): 1310-1314.

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