有机阴离子转运多肽1A2对药物转运的影响

摘要/Abstract

摘要： 有机阴离子转运多肽1A2(OATP1A2)是人体内重要的膜转运蛋白,在肝、肾、小肠、血脑屏障等组织部位进行表达,介导内、外源物质的跨细胞转运,对药物的吸收、分布和消除起着十分重要的作用。本文将对OATP1A2的组织分布和基本功能、基因多态性及其对药物转运的影响作一综述。

关键词: 有机阴离子转运多肽1A2, 药物转运, 药代动力学

Abstract: Organic anion transporting polypeptide 1A2(OATP1A2), expressed in liver, kidney, small intestine, blood-brain barrier and other organizations, is an important membrane transporter in humans. OATP1A2 mediates the trans-membrane transport of endogenous and exogenous materials, and plays a significant role in drug absorption, distribution and elimination. This review aimes to summarize the distribution, basic functions and gene polymorphism of OATP1A2, and its impact on drug transport.

Key words: Organic anion transporting polypeptide 1A2, Drug transport, Pharmacokinetics

中图分类号:

R969

彭丹, 夏春华, 熊玉卿. 有机阴离子转运多肽1A2对药物转运的影响[J]. 中国临床药理学与治疗学, 2010, 15(4): 464-469.

PENG Dan, XIA Chun-hua, XIONG Yu-qing. Effect on drug transport of OATP1A2[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(4): 464-469.

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