万古霉素治疗耐甲氧西林金黄色葡萄球菌的疗效和血药浓度分析

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (6): 673-677.

万古霉素治疗耐甲氧西林金黄色葡萄球菌的疗效和血药浓度分析

华俊彦, 田伟强, 朱雅艳, 虞惠康

丽水市中心医院药剂科,丽水 323000,浙江

收稿日期:2010-03-11 修回日期:2010-04-24 出版日期:2010-06-26 发布日期:2020-09-16
通讯作者: 田伟强,男,学士,主任药师,研究方向:医院药事管理和临床药学。 Tel: 0578-2681490 E-mail: lstianwq@126.com
作者简介:华俊彦,男,学士,副主任药师,研究方向:主要从事临床药学研究。Tel: 0578-2681490 E-mail: tankhua@126.com
基金资助:
温州医学院2007年度重大科研项目(B类):Z2007B045

Efficacy and plasma concentration analysis of Vancomycin in the treatment of methicillin-resistant Staphylococcus aureus infection

HUA Jun-yan, TIAN Wei-qiang, ZHU Ya-yan, YU Hui-kang

Department of Pharmacy, Lishui Central Hospital, Lishui 323000, Zhejiang,China

Received:2010-03-11 Revised:2010-04-24 Online:2010-06-26 Published:2020-09-16

摘要/Abstract

摘要： 目的: 探讨万古霉素治疗耐甲氧西林金黄色葡萄球菌感染的临床疗效、血药谷浓度、不良反应三者的关系。方法: 调查本院2008年1月-2009年10月住院部确诊为耐甲氧西林金黄色葡萄球菌感染并使用万古霉素治疗者82例,观察其临床疗效、细菌学疗效及不良反应,并测定其血药谷浓度。结果: 万古霉素血药谷浓度小于5 μg/mL、5~10 μg/mL及大于 10 μg/mL的治疗有效率分别为68.75%、72.73%和81.82%;细菌清除率分别为62.50%、68.18%和72.73%,1例血药谷浓度为 14.6 μg/mL的患者出现肾毒性。结论: 增加万古霉素血药谷浓度可提高治疗耐甲氧西林金黄色葡萄球菌感染的疗效和细菌清除率,但出现肾毒性不良反应几率也相应增大。

关键词: 万古霉素, 耐甲氧西林金黄色葡萄球菌, 血药谷浓度

Abstract: AIM: To investigate the relationship of clinical efficacy, blood trough concentration and adverse reavtion, which in the treatment of methicillin-resistant Staphylococcus aureus infection with Vancomycin. METHODS: The clinical data of 82 hospital patients who were infected by methicillin-resistant Staphylococcus aureus and treated with Vancomycin from January 2008 to October 2009 were retrospectively analyzed the clinic efficacy, bacteriological treatment, adverse reaction were observed, and the blook trough concentration was detected. RESULTS: The treatment effective rate of Vancomycin-blood trough concentration which was less than 5 μg/mL, in the range of 5-10 μg/mL, and greater than 10 μg/mL were 68.75%, 72.73% and 81.82%. The bacterial clearance rates were 62.50%, 68.18% and 72.73%. One case of blood trough concentration of 14.6 μg/mL in patients with renal toxicity. CONCLUSION: Increasing the blood trough concentration of Vancomycin can improve the treatment of methicillin-resistant Staphylococcus aureus infection in the efficacy and bacterial eradication rates, but the probability of renal toxicity adverse reactions will also increase accordingly.

Key words: Vancomycin, Methicillin-resistant Staphylococcus aureus, Blood trough concentration

中图分类号:

华俊彦, 田伟强, 朱雅艳, 虞惠康. 万古霉素治疗耐甲氧西林金黄色葡萄球菌的疗效和血药浓度分析[J]. 中国临床药理学与治疗学, 2010, 15(6): 673-677.

HUA Jun-yan, TIAN Wei-qiang, ZHU Ya-yan, YU Hui-kang. Efficacy and plasma concentration analysis of Vancomycin in the treatment of methicillin-resistant Staphylococcus aureus infection[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(6): 673-677.

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