CYP2C19基因多态性对药物代谢的影响及其个体化用药

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (8): 949-953.

CYP2C19基因多态性对药物代谢的影响及其个体化用药

严非, 夏春华, 熊玉卿

南昌大学医学院临床药理研究所,南昌 330006,江西

收稿日期:2010-07-21 修回日期:2010-08-21 出版日期:2010-08-26 发布日期:2020-09-17
通讯作者: 熊玉卿,女,教授,博士生导师,研究方向为临床药理学与药物代谢动力学。Tel: 0791-6361081 E-mail: xiongyuqing2009@hotmail.com
作者简介:严非,男,硕士研究生,研究方向为临床药理学。E-mail: yanfei19870915@163.com

Effect of CYP2C19 genetic polymorphism on drug metabolism and individualized therapy

YAN Fei, XIA Chun-hua, XIONG Yu-qing

Institute of Clinical Pharmacology, Medical College of Nanchang University, Nanchang 330006, Jiangxi, China

Received:2010-07-21 Revised:2010-08-21 Online:2010-08-26 Published:2020-09-17

摘要/Abstract

摘要： CYP2C19是一种重要的药物代谢酶,参与多种药物的体内代谢。该酶的活性在不同个体和种族之间存在着显著的差异。本文综述了CYP2C19酶的基因多态性对药物代谢的影响,以期为指导临床合理用药打下坚实的理论基础,确保临床用药的安全性和有效性,真正的实现个体化用药。

关键词: CYP2C19, 基因多态性, 药物代谢, 个体化用药

Abstract: CYP2C19 is an important durg-metabolizing enzyme involved in the metabolism of a variety of drugs in vivo. The enzymatic activity is significantly different in different individuals and races. This paper is about the effect of CYP2C19 genetic polymorphism on drug metabolism,in order to lay down a solid theory foundation for the guidance in clinical rational administration, ensure the safety and effectiveness of clinical usage, achieving individualized therapy in its true sense.

Key words: CYP2C19, Genetic polymorphism, Drug metabolism, Individualized therapy

中图分类号:

R969

严非, 夏春华, 熊玉卿. CYP2C19基因多态性对药物代谢的影响及其个体化用药[J]. 中国临床药理学与治疗学, 2010, 15(8): 949-953.

YAN Fei, XIA Chun-hua, XIONG Yu-qing. Effect of CYP2C19 genetic polymorphism on drug metabolism and individualized therapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(8): 949-953.

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