脑缺血动物模型及其实验治疗学应用

摘要/Abstract

摘要： 脑缺血是指由于大脑特定部位的血流供应受阻所导致的血氧不足或脑缺氧,以致不能满足供能的需要,造成脑组织死亡或脑梗塞/缺血性中风。脑缺血的病理生理机制以及缺血性脑损伤后的神经修复是当今神经科学研究的热点之一。动物模型的成功复制为脑缺血的实验治疗学研究起了巨大的推动作用。本文就国内外已经建立的弥漫性脑缺血、局灶性脑缺血动物模型的方法学文献作系统综述,同时列举这些模型的优缺点及其在实验治疗学中的应用,为实验性神经保护药物的药效学筛选提供科学指导。

关键词: 脑缺血, 动物模型, 弥漫性脑缺血, 局灶性脑缺血, 实验治疗学

Abstract: Brain ischemia, also known as cerebral ischemia, is due to insufficient blood flow to specific parts of the brain to meet metabolic demand, resulting poor oxygen supply or cerebral hypoxia and thus to the death of brain tissue or cerebral infarction/ischemic stroke.Currently pathophysiological mechanism of brain ischemia and nerve repair therapy following ischemia brain injury is one of the hottest issues in neuroscience research.Duplicating animal models for brain ischemia plays a vital role in promoting the investigation of experimental therapeutics.This article systemically reviews the methodological literature of animal models for global brain ischemia and focal cerebral ischemia, which has been established at home and abroad. Based upon the aforementioned models, their strengths and weaknesses and some typical applications in experimental therapeutics are simultaneously enumerated. All these information provides scientific guidance for the experimental neuroprotectant drug's pharmacodynamics screening.

Key words: Brain ischemia, Animal model, Global brain ischemia, Focal brain ischemia, Experimental therapeutics

中图分类号:

顾兵, 程翔, 金建波, 余日跃. 脑缺血动物模型及其实验治疗学应用[J]. 中国临床药理学与治疗学, 2010, 15(9): 1074-1080.

GU Bing, CHENG Xiang, JIN Jian-bo, YU Ri-yue. Animal models for brain ischemia and its application in experimental therapeutics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(9): 1074-1080.

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