瑞舒伐他汀药代动力学及与其他药物的相互作用研究进展

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (11): 1309-1314.

瑞舒伐他汀药代动力学及与其他药物的相互作用研究进展

温金华, 袁钊, 熊玉卿

南昌大学医学院临床药理研究所,南昌 330006 ,江西

收稿日期:2011-03-18 修回日期:2011-04-12 出版日期:2011-11-26 发布日期:2011-11-29
通讯作者: 熊玉卿,女,教授,博士生导师,研究方向:临床药理学与药物代谢动力学。Tel: 0791-6361195 E-mail: xyq1126@yahoo.com.cn
作者简介:温金华,男,博士研究生,研究方向:临床药理学。E-mail: wenjh810411@yahoo.com.cn
基金资助:
国家十一五科技重大专项“建立新药研发安全监测信息化技术平台”子课题“构建I期临床试验研究和风险监测的信息化监管技术平台”(2009ZX09309-003-02)

Study on pharmacokinetics of rosuvastatin and its drug interactions with other drugs

WEN Jin-hua, XIONG Yu-qing

Institute of Clinical Pharmacology, College of Medicine, Nanchang University, Nanchang 330006, Jiangxi,China

Received:2011-03-18 Revised:2011-04-12 Online:2011-11-26 Published:2011-11-29

摘要/Abstract

摘要： 瑞舒伐他汀是新一代他汀类药物,相对之前的他汀类药物,肝选择性更好;肝代谢少、消除半衰期长,具有更强的降脂作用,临床应用前景广泛;其耐受性良好,不良反应发生率与同类其他药物相似。本文对瑞舒伐他汀的药代动力学及与其他药物相互作用作一综述。以期为指导瑞舒伐他汀的临床用药打下坚实的理论基础,确保临床用药的安全性和有效性,真正实现临床上的个体化给药。

关键词: 瑞舒伐他汀, 药动学, 药物相互作用

Abstract: Rosuvastatin, a new generation of statins , has better liver selectivity, less metabolism and long elimination half-life.It has more lipid-lowering effect and a wide range prospects of clinical applications. Moreover, rosuvastatin has good tolerability and the incidence of adverse reactions was similar to other kind of statins. In this paper, rosuvastatin pharmacokinetics and pharmacokinetic interactions with other drugs are reviewed. In order to lay down a solid theory foundation for the guidance in clinical usage of Rosuvastatin, ensure the safety and effectiveness of clinical usage, achieving individualized therapy in its true sense.

Key words: Rosuvastatin, Pharmacokinetics, Drug interaetion

中图分类号:

R969.1

温金华, 袁钊, 熊玉卿. 瑞舒伐他汀药代动力学及与其他药物的相互作用研究进展[J]. 中国临床药理学与治疗学, 2011, 16(11): 1309-1314.

WEN Jin-hua, XIONG Yu-qing. Study on pharmacokinetics of rosuvastatin and its drug interactions with other drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(11): 1309-1314.

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