紫杉醇白蛋白纳米粒抗肿瘤临床研究进展

摘要/Abstract

摘要： 以白蛋白为载体的紫杉醇纳米粒在抗肿瘤方面发挥了重要作用。本文对紫杉醇白蛋白纳米粒体内药动学过程、纳米粒转运机制进行探讨,并就近几年来紫杉醇白蛋白纳米粒在乳腺癌、非小细胞肺癌及其他恶性肿瘤方面的临床研究作一综述,为临床应用提供借鉴。

关键词: 紫杉醇, 白蛋白纳米粒, 临床研究

Abstract: Albumin is a vital drug carrier for nanoparticle paclitaxel in the anti-cancer treatment.This paper reviewed the pharmacokinetics and mechanism of nanoparticle transport of nanoparticle albumin-bound paclitaxel,and summarized the recent clinical trials of nanoparticle albumin-bound paclitaxel in breast cancer,non-small cell lung cancer,and other malignant treatment which could be a reference for its clinical use.

Key words: Paclitaxel, Nanoparticle albumin-bound, Clinical trial

中图分类号:

蔡鑫君, 徐颖颖, 倪坚军. 紫杉醇白蛋白纳米粒抗肿瘤临床研究进展[J]. 中国临床药理学与治疗学, 2011, 16(6): 716-720.

CAI Xin-jun, XU Ying-ying, NI Jian-jun. Clinical research advancement of nanoparticle albumin-bound paclitaxel in anti-cancer treatment[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(6): 716-720.

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