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中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (9): 1039-1041.

• 药物治疗学 • 上一篇    下一篇

利培酮和奥氮平对精神分裂症患者血浆非酶类抗氧化物水平的影响

温盛霖, 程敏锋, 王厚亮   

  1. 中山大学附属第三医院精神科,广州 510630,广东
  • 收稿日期:2011-07-04 修回日期:2011-08-12 出版日期:2011-09-26 发布日期:2011-10-11
  • 作者简介:温盛霖,男,硕士,副主任医师,硕士生导师,研究方向:心身医学。Tel: 13312883618 E-mail: wenshl@mail.sysu.edu.cn
  • 基金资助:
    2008广东省科技计划项目(2008B030301068)

Comparative study of risperidone and olanzapine on plasma non-enzyme antioxidants levels in the schizophrenic patients

WEN Sheng-lin, CHENG Min-feng, WANG Hou-liang   

  1. Department of Psychology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong, China
  • Received:2011-07-04 Revised:2011-08-12 Online:2011-09-26 Published:2011-10-11

摘要: 目的: 比较利培酮和奥氮平对首发精神分裂症患者的血浆非酶类抗氧化物水平的影响。方法: 用随机对照方法对92例精神分裂症患者进行利培酮和奥氮平治疗4周,以PANSS评定疗效,检测患者治疗前后的血清白蛋白、总胆红素及尿酸水平。结果: (1)2组间在治疗前和治疗后4周的血清白蛋白、总胆红素及尿酸水平的差异比较均无统计学意义(P>0.05),利培酮组治疗4周后的血清白蛋白和总胆红素水平低于治疗前水平,差异有统计学意义(P<0.05),奥氮平组治疗4周后的总胆红素水平低于治疗前水平,差异有统计学意义(P<0.05)。(2)2两组临床疗效比较差异无统计学意义(P>0.05)。结论: 经治疗后精神分裂症患者血浆非酶类抗氧化物水平发生改变,利培酮和奥氮平对它们的影响相似。

关键词: 精神分裂症, 白蛋白, 尿酸, 胆红素, 利培酮, 奥氮平

Abstract: AIM: To compare the effects of risperidone and olanzapine on plasma non-enzyme antioxidants levels in the schizophrenic patients. METHODS: Using randomized study, schizophrenic patients were divided into risperidone and olanzapine group respeetively for four weeks treatment, and evaluated by the Positive and Negative Syndrome Scale (PANSS). Serum levels of Albumins, Uric Acid, and Bilirubin were tested. RESULTS: (1)There were no difference between two groups about the levels of Albumins, Uric Acid, and Bilirubin before treatment and after 4 weeks treatment (P>0.05). The levels of Albumins and Bilirubin after 4 weeks treatment in risperidone group were lower than those before treatment (P<0.05). The levels of Bilirubin after 4 weeks trea tment in olanzapine group were lower than tho se before treatment (P<0.05).(2)There were no difference between two groups about the effective rate (P>0.05). CONCLUSION: Plasm a non-enzy meantioxidants levels in the schizophrenic patients changed after treatment, and there are no signif-icant differences in the effects of rispe ridone and olanzapine on plasma non-enzy me antiox idants levels.

Key words: Schizophreni, A lbumins, U ric Acid, Bilirubin, Olanzapine, Risperido ne

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