核受体对细胞色素P450的调控作用研究进展

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (10): 1195-1200.

• 综述与讲座 • 上一篇

核受体对细胞色素P450的调控作用研究进展

何芳, 曾彩雯, 夏春华, 熊玉卿

南昌大学临床药理研究所,南昌 330006,江西

收稿日期:2012-03-13 修回日期:2012-07-03 发布日期:2012-10-19
通讯作者: 夏春华,通信作者,男,教授,主要从事药物代谢动力学及临床药理学研究。Tel: 0791-86360654 E-mail: xch720917@yahoo.com.cn
作者简介:何芳,女,硕士研究生,主要从事药物代谢动力学研究。Tel: 0791-86360654 E-mail: 695952030@qq.com
基金资助:
国家自然科学基金(81060275; 81160411); 国家十二五重大专项(2011ZX09302-007-03); 江西省自然科学基金与科技支撑计划(2009GZY0141; 2009BSB09600)

Regulation of nuclear receptors on cytochrome P450 enzymes

HE Fang, ZENG Cai-wen, XIA Chun-hua, XIONG Yu-qing

Clinical Pharmacology Institution, Nanchang University, Nanchang 330006, Jiangxi , China

Received:2012-03-13 Revised:2012-07-03 Published:2012-10-19

摘要/Abstract

摘要： 核受体是一组配体依赖性转录因子超家族,与药物代谢过程中的基因表达调控密切相关,在机体的生长发育、新陈代谢、以及许多生理过程中发挥着重要作用,体内主要由组成型雄甾烷复体(CAR)、PXR、GR、AhR和PPAR几种核受体调控细胞色素P450基因表达介导药物代谢。本

关键词: 核受体, 细胞色素P450, 调控作用

Abstract: Nuclear receptors are one superfamily of ligand-activated transcription factors and relate to regulating gene expression in drug metabolic processes. Nuclear receptors play an important role in growing development, metabolism and many physiological processes. Nuclear receptors including CAR, PXR, GR, AhR and PPAR mediate drug metabolism by regulating cytochrome P450 gene expression in vivo. This paper reviewed the regulation effect of several nuclear receptors on cytochrome P450 gene in order to provide molecular mechanism for drug interaction.

Key words: Nuclear receptors, Cytochrome P450, Regulate

中图分类号:

R969

何芳, 曾彩雯, 夏春华, 熊玉卿. 核受体对细胞色素P450的调控作用研究进展[J]. 中国临床药理学与治疗学, 2012, 17(10): 1195-1200.

HE Fang, ZENG Cai-wen, XIA Chun-hua, XIONG Yu-qing. Regulation of nuclear receptors on cytochrome P450 enzymes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(10): 1195-1200.

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核受体对细胞色素P450的调控作用研究进展

Regulation of nuclear receptors on cytochrome P450 enzymes

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