奥氮平与利培酮治疗老年精神分裂症患者疗效及执行功能比较

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (7): 812-815.

奥氮平与利培酮治疗老年精神分裂症患者疗效及执行功能比较

杭荣华¹, 程万良², 王瑞权³, 吴明飞²

¹皖南医学院心理学教研室,芜湖 241002,安徽;
²芜湖市第四人民医院精神科,芜湖 241006,安徽;
³皖南医学院弋矶山医院医学心理科,芜湖 241001,安徽

收稿日期:2012-02-25 修回日期:2012-04-03 发布日期:2012-07-17
作者简介:杭荣华,女,硕士,副教授,研究方向:精神障碍的心理治疗、神经心理学。Tel: 13033033593 E-mail: rhhang311@126.com
基金资助:
2012年度皖南医学院重点科研项目培育基金(WK2012Z04)

Efficacy and executive function of olanzapine and risperidone in the treatment of elderly patients with schizophrenia

HANG Rong-hua¹, CHENG Wan-liang², WANG Rui-quan³, WU Ming-fei²

¹Department of Psychology, Wannan Medical College, Wuhu 241002, Anhui, China;
²Department of Psychiatry ,Wuhu Fourth People's Hospital, Wuhu 241006,Anhui,China;
³Department of Psychology, Affiliated Yijishan Hospital, Wannan Medical College,Wuhu 241001,Anhui,China

Received:2012-02-25 Revised:2012-04-03 Published:2012-07-17

摘要/Abstract

摘要： 目的: 比较奥氮平与利培酮治疗老年精神分裂症的疗效及对执行功能的影响。 方法: 84例老年精神分裂症患者随机分为奥氮平组(43例)和利培酮组(41例),于治疗前及治疗后第8周末采用阳性与阴性症状量表(PANSS)和威斯康星卡片分类测验(WCST)评定疗效和执行功能,分别比较每组治疗前后及两组间的结果。 结果: 治疗后奥氮平组的有效率及显效率分别为 90.6％和 67.4%,利培酮组的有效率及显效率分别为 92.6％和 68.3％,两者差异无统计学意义(P>0.05)。治疗后奥氮平组的阴性症状分低于利培酮组(P<0.01)。利培酮组WCST的完成分类数低于奥氮平组,持续性错误数和总错误数高于利培酮组(P<0.01)。 结论: 奥氮平和利培酮均能有效改善老年精神分裂症的症状和执行功能,但奥氮平对阴性症状和执行功能的改善效果更好。

关键词: 奥氮平, 利培酮, 老年, 精神分裂症, PANSS, 执行功能

Abstract: AIM: To explore the difference on efficacy and executive function between olanzapine and risperidone in treatment of elderly patients with schizophrenia. METHODS: 84 elderly patients with schizophrenia were randomly divided into olanzapine group (43 cases) and risperidon group (41 cases) treated for 8 weeks. The efficacy was assessed with the positive and negative symptoms scale (PANSS) and the executive function was evaluated with Wisconsin Card Sorting Test (WCST) in baseline and after 8 weeks of treatment. RESULTS: After 8 weeks of treatment, the efficacy rate of olanzapine was 90.6% , in which 67.4% was improved markedly. The efficacy rate of risperidon was 92.6%, in which 68.3% were improved markedly. There were no differences between two groups (P>0.01). The score of negative symptom of olanzapine group was significantly lower than that of risperidon group(P<0.05). The score of categories control in risperidon group was significantly lower than that in olanzapine group, persistent errors and response error were higher than that in olanzapine group(P<0.01). CONCLUSION: Both olanzapine and risperidon can improve the symptom and executive function of elderly patients with schizophrenia. Olanzapine is better than risperidon in improving negative symptom and executive function.

Key words: Olanzapine, Risperidon, Elderly patient, Schizophrenia, PANSS, Executive function

中图分类号:

R749

杭荣华, 程万良, 王瑞权, 吴明飞. 奥氮平与利培酮治疗老年精神分裂症患者疗效及执行功能比较[J]. 中国临床药理学与治疗学, 2012, 17(7): 812-815.

HANG Rong-hua, CHENG Wan-liang, WANG Rui-quan, WU Ming-fei. Efficacy and executive function of olanzapine and risperidone in the treatment of elderly patients with schizophrenia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(7): 812-815.

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