柚皮苷的药物代谢动力学研究概况与进展

摘要/Abstract

摘要： 柚皮苷是一种二氢黄酮类化合物,具有促进胃肠蠕动功能,主要存在于枳壳、枳实、骨碎补、化橘红等中药中。柚皮苷的口服吸收差,体内分布广泛,主要经开环、脱氢、裂解等反应产生对羟基苯丙酸、对羟基桂皮酸等代谢产物而排出体外。同时柚皮苷还能够通过抑制部分转运体、代谢酶的活性与其他药物发生相互作用,从而影响其他药物的代谢过程。本文通过综述柚皮苷的药物代谢动力学特征及柚皮苷对其他药物的代谢动力学的影响,发现柚皮苷代谢过程的相互作用机制及基因多态性对其药代动力学特征的影响尚需深入研究。

关键词: 柚皮苷, 药代动力学, 药物相互作用

Abstract: Naringin is a dihydroflavone compound with the function of promoting gastrointestinal motility, which was found in some Chinese medicine such as Fructus Aurantii, Fructus Aurantii Immaturus, Rhizoma Drynariae, Pummelo Peel and so on. Naringin's oral absorb was bad, extensive distributed in the body, and produced metabolin like p-hydroxybenzoic acid and p-hydroxycinnamic acid by the way of opening loop, dehydrogenation, splitting, then eliminated from the body. Naringin also could interact with other drugs with the inhibiton of some transporters and metabolic enzymes, then influenced the pharmacokinetics of other drugs. This text reviews the pharmacokinetics of naringin and it's influence on other drugs, then points out that the mechanism of interaction through the metabolic process and the influence of genetic polymorphism on its pharmacokinetics still need to be studied.

Key words: Naringin, Pharmacokinetic, Drug interaction

中图分类号:

R969.1

朱宏平, 熊玉卿. 柚皮苷的药物代谢动力学研究概况与进展[J]. 中国临床药理学与治疗学, 2013, 18(11): 1297-1303.

ZHU Hong-ping, XIONG Yu-qing. Overview and progress on the study of the pharmacokinetics of naringin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1297-1303.

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