益母草碱药理作用的分子机制研究进展

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (12): 1419-1423.

益母草碱药理作用的分子机制研究进展

贺春晖, 赵懿清, 李霞, 周路遥

无锡市第三人民医院药剂科,无锡 214041,江苏

收稿日期:2013-03-16 修回日期:2013-11-12 出版日期:2013-12-26 发布日期:2014-01-04
通讯作者: 李霞,女,硕士,主管药师,研究方向:分子药理学。Tel: 0510-81195715 E-mail: lixia.ahmu.cn@163.co
作者简介:贺春晖,女,硕士,药师,研究方向:临床药学。Tel: 18626378278 E-mail: hechunhui11230@163.com
基金资助:
江苏省中医药管理局中医药科技项目(LB09094)

Research progress in molecular mechanism of the pharmacological actions of leonurine

HE Chun-hui, ZHAO Yi-qing, LI Xia, ZHOU Lu-yao

Department of Pharmacy, the Third People's Hospital of Wuxi, Wuxi 214041, Jiangsu, China

Received:2013-03-16 Revised:2013-11-12 Online:2013-12-26 Published:2014-01-04

摘要/Abstract

摘要： 益母草碱(Leonurine)是存在于中药益母草的特异生物碱。近年来,文献报道了许多关于益母草碱异于传统适应症的药理作用和机制研究,如心血管保护、中枢保护、抗糖尿病等作用,其机制可能与其抗氧化、抗细胞凋亡和调节线粒体功能和抗炎等作用有关。本文就益母草碱的这些药理作用及其作用机制作一简要综述,以促进益母草碱研究的开展及临床上更好的应用。

关键词: 益母草碱, 分子机制, 心血管保护, 中枢保护, 抗糖尿病

Abstract: Leonurine is the unique compound found only in Herba Leonuri. In recent years, there are many reports about molecular mechanisms of leonurine pharmacological actions, which is different from the traditional indications, for instance, cardiovascular protective, neuroprotection, and anti-diabetic effects, et al. The underlying mechanisms may be related to its antioxidant, antiapoptotic, modulation of mitochondrial function and anti-inflammatory and many others. This article summarizes the pharmacological actions and the underlying molecular mechanisms of leonurine, the purpose of which is to deepen the relevant study of leonurine and facilitate its clinical use.

Key words: Leonurine, Molecular mechanism, Cardiovascular protective, Neuroprotection, Anti-diabetic

中图分类号:

R966

贺春晖, 赵懿清, 李霞, 周路遥. 益母草碱药理作用的分子机制研究进展[J]. 中国临床药理学与治疗学, 2013, 18(12): 1419-1423.

HE Chun-hui, ZHAO Yi-qing, LI Xia, ZHOU Lu-yao. Research progress in molecular mechanism of the pharmacological actions of leonurine[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1419-1423.

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