孕烷X受体生物特性及其在药物代谢中的作用研究进展

摘要/Abstract

摘要： 核受体孕烷X受体是一类生物体内广泛分布的激素和环境感受器,不仅可参与能量、胆固醇、胆汁酸等物质的代谢以及调节炎症反应,还可以调控Ⅰ相、Ⅱ相药物代谢酶和相关药物转运蛋白的表达而调节药物代谢,其作用对维持机体诸如细胞增殖分化、生长发育、新陈代谢、稳态维持等多种生理功能有重要意义。本文就孕烷X受体结构功能、生物学效应以及其对药物代谢酶和药物转运调节的作用等作一综述。

关键词: 核受体, 孕烷X受体, 药物代谢

Abstract: The nuclear pregnane X receptor(PXR) is a kind of hormones and environmental receptors and is widely distributed in organism.PXR not only involved in the metabolism of energy,cholesterol,bile acids and other substances as well as regulation of the inflammatory response,and also regulates phase Ⅰ,Ⅱ phase drug metabolizing enzymes and the related the expression of drug transporters. It is important for the body to maintain a variety of physiological functions such as cell proliferation and differentiation, growth and development, metabolism, homeostasis.This paper reviewed the PXR structure and function, biological effects and the regulation of drug-metabolizing enzymes and drug transporters.

Key words: Nuclear receptor, PXR, Drug metabolism

中图分类号:

R968

陈群, 徐喆, 孙华, 谢海棠. 孕烷X受体生物特性及其在药物代谢中的作用研究进展[J]. 中国临床药理学与治疗学, 2013, 18(3): 241-246.

CHEN Qun, XU Zhe, SUN Hua, XIE Hai-tang. Advances on biological characteristics of PXR and its effect on drug metabolism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(3): 241-246.

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