组蛋白去甲基化酶JMJD1A及其生物学功能研究进展

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (3): 325-330.

组蛋白去甲基化酶JMJD1A及其生物学功能研究进展

湛敏, 周宏灏

中南大学临床药理研究所,长沙 410078,湖南

收稿日期:2013-01-07 修回日期:2013-02-12 出版日期:2013-03-26 发布日期:2013-04-02
通讯作者: 周宏灏,通信作者,男,院士,博士生导师,主要从事遗传药理学和临床药理学研究。Tel: 0731-84805379 E-mail: hhzhou@163.com
作者简介:湛敏,女,博士研究生,主要从事遗传药理学和临床药理学研究。Tel: 0731-84805380 E-mail: zhanminhao@163.com

Histone demethylase JMJD1A and its biological functions

ZHAN Min, ZHOU Hong-hao

Instìtute of Clinìcal Pharmacology, Hunan Key Laboratory of Pharmacogenetìcs, Central South University, Changsha 410078, Hunan, China

Received:2013-01-07 Revised:2013-02-12 Online:2013-03-26 Published:2013-04-02

摘要/Abstract

摘要： 组蛋白去甲基化酶JMJD1A(Jumonji domain containing 1A)通过羟基化作用使组蛋白赖氨酸去甲基而参与转录调节,参与精子生成、能量代谢、干细胞调控,与肿瘤的发生和发展相关,是潜在的抗肿瘤药物的作用靶点。本文就JMJD1A的结构、催化反应机理、底物特异性、生物学功能和抑制剂作一综述。

关键词: JMJD1A, 基因转录调控, 组蛋白去甲基化酶

Abstract: Histone demethylase JMJD1A (Jumonji domaincontaining protein 1A) regulates gene transcription by hydroxylation pathway, which demethylases mono- and di-methy H3K9 (H3K9me1/2). JMJD1A play roles in spermatogenesis, energy metabolism, regulation of stem cell as well as the initiation and progress of cancer. Here, we review the structure, catalytic mechanism, substrate specificity, biological function and inhibitor of JMJD1A.

Key words: JMJD1A, Histone demethylase, Gene transcriptional regulation

中图分类号:

R969.8

湛敏, 周宏灏. 组蛋白去甲基化酶JMJD1A及其生物学功能研究进展[J]. 中国临床药理学与治疗学, 2013, 18(3): 325-330.

ZHAN Min, ZHOU Hong-hao. Histone demethylase JMJD1A and its biological functions[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(3): 325-330.

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