中国皖南地区728例恶性淋巴瘤的构成分析

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (4): 388-393.

中国皖南地区728例恶性淋巴瘤的构成分析

陈冰¹, 张帆², 卢林明¹, 朱晓群¹, 刘银华², 何雷²

¹皖南医学院病理教研室, ²皖南医学院附属弋矶山医院病理科,芜湖 241001,安徽

收稿日期:2012-12-29 出版日期:2013-04-26 发布日期:2013-04-26
作者简介:陈冰,男,在读硕士,讲师,研究方向:淋巴瘤病理。Tel: 13855313312 E-mail: 281993214@qq.com
基金资助:
安徽高校省级自然科学研究项目(KJ2013B322)

Analysis distribution of 728 cases with malignant lymphoma by wannan area of China

CHEN Bing¹, ZHANG Fan², LU Lin-ming¹, ZHU Xiao-qun¹, LIU Yin-hua², He Lei²

¹ Department of Pathology Wannan Medical College; ² Department of Pathology, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China

Received:2012-12-29 Online:2013-04-26 Published:2013-04-26

摘要/Abstract

摘要： 目的: 初步了解中国皖南地区恶性淋巴瘤的构成情况,探讨本地区恶性淋巴瘤的流行病学特点。方法: 收集皖南医学院附属弋矶山医院病理科2003.03-2012.03间诊断明确的淋巴瘤标本,全部病例经重新HE切片染色、免疫组化(Envision二步)法辅助检测,部分病例采用EBER原位杂交法(EBER-ISH)协助诊断,并参照2008版WHO关于淋巴造血组织肿瘤的分类进行组织学诊断和分型。结果: 728例中霍奇金淋巴瘤(HL)占 9.34%(68/728),非霍奇金淋巴瘤(NHL)占 90.66%(660/728),NHL中B细胞来源占 77.42%(511/660)。T/NK细胞来源占 22.58%(149/660),此外,在收集的淋巴瘤标本中,弥漫性大B细胞淋巴瘤(DLBCL)占 49.73%(362/728),其余较多见的六大类型依次为结外NK/T细胞淋巴瘤61例占 8.37%,黏膜相关淋巴组织结外边缘区淋巴瘤(MALT)56例占 7.69%,外周T细胞淋巴瘤50例占 6.87%,套细胞淋巴瘤36例占 4.95%,经典霍奇金淋巴瘤(结节硬化型)32例占 4.40%,经典霍奇金淋巴瘤(混合细胞型)31例占 4.26%。男性433例,女性295例,男女性别比为 1.47∶1,年龄最小5岁,最大90岁,中位年龄61岁;血管免疫母细胞性T细胞淋巴瘤男性发病率为 86.6%(13/15)。最好发的部位依次为淋巴结、胃、肠、鼻咽部、扁桃体、涎腺、甲状腺、眼眶、骨和脾等。结论: 中国皖南地区HL以结节硬化型和混合型居多,未见"双峰性",且以原发于左颈淋巴结多见。NHL中还是DLBCL为最多见,淋巴瘤血管免疫母细胞性T细胞淋巴瘤男性、67岁以上发病率较高,提示恶性淋巴瘤在亚类和分类上具有明显地域性的差异。

关键词: 淋巴瘤, 分布, 流行病学

Abstract: AIM: To initiate us into understand constituent ratio and study the epidemiologic characteristics of malignant lymphoma by wannan area in China.METHODS: Case of the total 728 malignant lymphoma patients were selected from yijishan hospital of wannan medical college during 2003-2012. The diagnosis of malignant lymphoma accords with the hematopoietic and lymphoid tissue tumours on WHO classification (2008) by HE staining, immunohistochemistry (Envision two step) method and EBER-ISH method.RESULTS: Among the 728 cases, Hodgkin's lymphoma (HL) 68 cases(9.34%), non-Hodgkin's lymphoma (NHL) 660 cases (90.66%). Among NHL, 511 cases secreted from B cells (77.42%), 149 cases secreted from T/NK cells (22.58%). Among the 728 cases, the most common subtype was diffuse large B cell lymphoma (DLBCL) 362 cases (49.73%), the remaining six subtype were extranodal NK/T-cell lymphoma 61 cases (8.37%), extranodal marginal zone B-cell lymphoma (MALT) 56 cases (7.69%), perpheral T-cell lymphoma 50 cases(6.87%), mantle cell lymphomacases 36 cases (4.95%), nodular sclerosis Hodgkin's lymphoma 32 cases (4.40%), mixed cellularity Hodgkin's lymphoma 31 cases (4.26%). The patients comprised 433 males and 295 (with a male to female ratio of 1.47∶1, with a median age of 61 years (range 5-90). The male ratio of Angioimmunoblastic T-cell lymphoma patients was 86.6% (13/15). Their predominant loci were lymph node, gastric, intestinal, nasopharynx, tonsil, salivary gland, thyroid, orbital, bone, spleen.CONCLUSION: Two common kinds of HL are nodular sclerosis Hodgkin's lymphoma, mixed cellularity Hodgkin's lymphoma. No twin-peak character are found. HL are often located on left cervical. The most common subtype is DLBCL among NHL. The incidence of Angioimmunoblastic T-cell lymphoma is higher in male and 67 years old. The incidence and subtype distribution of lymphoid neoplasms has obviously regional differences.

Key words: Lymphoma, Distribution, Epidemiology

中图分类号:

R733

陈冰, 张帆, 卢林明, 朱晓群, 刘银华, 何雷. 中国皖南地区728例恶性淋巴瘤的构成分析[J]. 中国临床药理学与治疗学, 2013, 18(4): 388-393.

CHEN Bing, ZHANG Fan, LU Lin-ming, ZHU Xiao-qun, LIU Yin-hua, He Lei. Analysis distribution of 728 cases with malignant lymphoma by wannan area of China[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 388-393.

参考文献

[1] Swerdlow S. WHO classification of tumours of haematopoietic and　lymphoid tissues[M]. 4th eds. Lyon: IARC Press, 2008, 157-334.
[2] Anderson JR, Armitage JO, Weisenburger DD. Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin's Lymphoma Classification Project [J]. Ann Oncol, 1998, 9(7): 717-720.
[3] Wang JF, Wang YZ, Chen ZW, et al. Prevalence of lymphoma subtypes in Shanxi according to latest WHO classification [J]. Zhonghua Bing Li Xue Za Zhi, 2006, 35(4): 218-223.
[4] 王晓卿, 徐钢, 李娟, 等. 淋巴瘤589例构成分析[J]. 临床与实验病理学杂志, 2011, 27(12): 1356-1358.
[5] JM Kim, YH Ko, SS Lee, et al. WHO classification of malignant lymphomas in Korea: report of the third nationwide study[J]. Korean J Pathol, 2011, 45(3): 254-260.
[6] Lee MY, Tan TD, Feng AC, et al. Clinicopathological analysis of malignant lymphoma in Taiwan, defined according to the World Health Organization classification[J]. Haematologica, 2005, 90(12): 1703-1705.
[7] Lee SS, Cho KJ, Kim CW, et al. Clinicopathologic alanalysis of 501 non-Hodgkin's lymphomas in Korea according to the revised European-American classification of lymphoid neoplasms[J]. Histopathology, 1999, 35(4): 345-354.
[8] Luminari S, Cesaretti M, Rashid I, et al. Incidence,clinical characteristics and survival of malignant lymphomas: a population based study from a cancer registry in northern Italy[J]. Hematol Oncol, 2007, 25(4): 189-197.
[9] Hans CP, Weiesnburger DD, Greiner TC, et al. Conifrmaiton of the molecular classficaiton of difuse large B-cell lymphoma by immunohistochemistry using a itssue microarray [J]. Blood, 2004, 103(1): 275-282.
[10] Carreon JD, Mor ton LM, Devesa SS, et al. Incidence of lymphoid neoplasms by subtype among six Asian ethnic groups in the United States,1996-2004[J]. Cancer Causes Control, 2008, 19(10): 1171-1181.
[11] Ohshima K, Kikuchi M, Eguchi F, et al. Analysis of Epstein viral genomes in lymphoid malignancy using southerm blotting polymerase chain reaction and in situ hybridization[J]. Virchows Arch B Cell Pathol Incl Mol Pathol, 1990, 159(6): 383-390.
[12] Roman E, Smith AG. Epidemiology of lymphomas[J]. Histopathology, 2011, 58(1): 414.

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