JNK信号通路与细胞凋亡关系的研究进展

摘要/Abstract

摘要： c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)信号通路是近20年来发现的与细胞分化、细胞凋亡、应激反应以及多种人类疾病的发生和发展关系非常密切的通路之一,其生物化学功能和对细胞生理、病理情况下的调节作用一直被国内外学者所关注。近年来,研究发现JNK信号通路在调控细胞凋亡中发挥重要作用,通过调节JNK信号通路有望成为治疗细胞凋亡引起的疾病的重要靶点。本文就其生物学功能及其与细胞凋亡关系作一阐述。

关键词: JNK信号通路, 细胞凋亡, 丝裂原活化蛋白激酶

Abstract: JNK pathway is closely associated with cell differentiation, apoptosis, stress response and many hunman diseases in the past 20 years, whose biochemical function, regulation under cell physiology and pathology are constantly noticed by domestic and foreign scholars. Recently, more research suggests that it plays an important role in regulating apoptosis, and it will be an important potential target for treatment of apoptosis-associated disease by regulating JNK signal pathway. In summary, the physiological and pathophysiological functions of JNK pathway and relation with apoptosis have been reviewed.

Key words: JNK pathway, Apoptosis, Mitogen activated protein kinase

中图分类号:

R965.2

魏娜, 贺海波, 张长城, 袁丁, 王婷. JNK信号通路与细胞凋亡关系的研究进展[J]. 中国临床药理学与治疗学, 2013, 18(7): 807-812.

WEI Na, HE Hai-bo, ZHANG Chang-cheng, YUAN Ding, WANG Ting. Research development between JNK pathway and apoptosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(7): 807-812.

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