2型糖尿病患者血清γ-谷氨酰转移酶与左室舒张功能关系的研究

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (8): 914-917.

2型糖尿病患者血清γ-谷氨酰转移酶与左室舒张功能关系的研究

楼晓佳

温州医学院附属东阳医院内分泌科,东阳 322100,浙江

收稿日期:2012-12-18 修回日期:2013-07-05 出版日期:2013-08-26 发布日期:2013-07-31
作者简介:楼晓佳,女,本科,副主任医师,研究方向:糖尿病的发病机制和治疗。Tel: 0579-89605131 E-mail: zjhdmr@163.com

Correlation study of serum γ-glutamyltransferase and left ventricular diastolic function in type 2 diabetes mellitus

LOU Xiao-jia

Department of Endocrinology, Wenzhou Medical College Affiliated Dong-yang Hospital,Dongyang 322100, Zhejiang,China

Received:2012-12-18 Revised:2013-07-05 Online:2013-08-26 Published:2013-07-31

摘要/Abstract

摘要： 目的: 探讨血清γ-谷氨酰转移酶在2型糖尿病患者血清中的表达及其与左室舒张功能的关系。方法: 选择2型糖尿病患者46例,按是否有左室舒张功能不全分为两组,均检测血γ-谷氨酰转移酶、甘油三酯、总胆固醇等水平。心脏超声评估二尖瓣舒张早期血流速度(E)与二尖瓣舒张晚期血流速度(A)的比值(E/A)以评价左室舒张功能。结果: 两组患者性别、体重指数、收缩压、舒张压、糖化血红蛋白、总胆固醇及甘油三酯比较差异均无统计学意义(P＞0.05);左室舒张功能不全组γ-谷氨酰转移酶明显高于左室舒张功能正常组,差异具有统计学意义(P＜0.01)。左室舒张功能不全组患者γ-谷氨酰转移酶与E/A值明显负相关(r=-0.681,P＜0.000)。结论: 2型糖尿病伴左室舒张功能不全患者血清γ-谷氨酰转移酶水平升高。γ-谷氨酰转移酶可能是2型糖尿病患者左室舒张功能不全的一个标志。

关键词: γ-谷氨酰转移酶, 糖尿病,2型, 左室舒张功能

Abstract: AIM: To detect the level of serum γ-glutamyltransferase and evaluate it's relationship with left ventricular diastolic function in type 2 diabetes mellitus.METHODS: A cross-sectional study of 46 type 2 diabetes patients with or without left ventricular diastolic dysfunction were divided into two groups.The levels of serum γ-glutamyltransferase,TC and TG were analyzed.Left ventricular diastolic function was assessed by pulsed Doppler tissue imaging and was determined by ratio E wave/A wave.RESULTS: There were no significant difference about sex, BMI,systolic blood pressure, diastolic blood pressure, HbA1c,total cholesterol and triglyceride in two groups of patients(P＞0.05). Compared with the left ventricular diastolic function group,the level of serum γ-glutamyltransferase was obviously higher in left ventricular diastolic dysfunction group,there was significant difference(P＜0.01). Negative correlations were found between γ-glutamyltransferase and E/A in left ventricular diastolic dysfunction group(r=-0.681,P＜0.000).CONCLUSION: The level of serum γ-glutamyltransferase was increased in type 2 diabetic patients with left ventricular diastolic dysfunction.The level of serum γ-glutamyltransferase might be an marker of diastolic dysfunction in type 2 diabetes patients.

Key words: γ-glutamyltransferase, Diabetes mellitus, Type 2, Left ventricular diastolic function

中图分类号:

R587.1

楼晓佳. 2型糖尿病患者血清γ-谷氨酰转移酶与左室舒张功能关系的研究[J]. 中国临床药理学与治疗学, 2013, 18(8): 914-917.

LOU Xiao-jia. Correlation study of serum γ-glutamyltransferase and left ventricular diastolic function in type 2 diabetes mellitus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(8): 914-917.

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