MicroRNA-34用于肿瘤治疗的基础研究

摘要/Abstract

摘要： MicroRNA-34(miR-34)调节多条信号通路上的靶基因发挥阻滞细胞周期,诱导细胞凋亡,抑制肿瘤干细胞、抑制转移以及化疗增敏的作用,从而抑制肿瘤的生长与转移。越来越多的证据表明,miR-34有可能成为肿瘤治疗的新靶点。本文综述了miR-34家族的生物学功能及其分子机制,以及在动物肿瘤模型中开展miR-34相关基因治疗的前期研究,揭示了miR-34用于肿瘤临床治疗的可能性。

关键词: MicroRNA-34, 肿瘤, 基因治疗

Abstract: MicroRNA-34(miR-34) inhibits many target genes involved in multiple oncogenic signaling pathways. The broad activity of miR-34 includes induction of cell cycle arrest and apoptosis, inhibition of tumor stem cells and metastasis and the anti-chemoresistance. There are increasing evidence suggesting that miR-34 plays a crucial role in cancer diseases and may be a potential therapeutic target. This review summarizes the biological function and molecular mechanisms of the miR-34 family, pharmacologies in animal tumor models, and reveals the possibility of miR-34 replacement therapy for the clinical treatment of tumor.

Key words: MicroRNA-34, Tumor, Gene therapy

中图分类号:

李征, 向开敏, 彭淑平, 李桂源. MicroRNA-34用于肿瘤治疗的基础研究[J]. 中国临床药理学与治疗学, 2014, 19(1): 67-73.

LI Zheng, XIANG Kai-ming, PENG Shu-ping, LI Gui-yuan. Basic research of microRNA-34 for cancer therapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(1): 67-73.

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