食物对细胞色素P450药物代谢酶的影响

摘要/Abstract

摘要： 细胞色素P450酶系在大多数内源性和外源性分子的生物氧化过程中发挥重要的作用,尤其在药物代谢方面。CYP450酶个体差异大,除了遗传因素的影响外,食物等外界因素也可能影响其活性或表达,从而影响经酶代谢药物的疗效和不良反应。故本文就食物因素对细胞色素P450酶影响的相关研究进行综述。

关键词: 食物, 细胞色素P450酶, 抑制, 诱导

Abstract: Cytochrome P450 (CYP450) enzymes play important roles in the biological oxidation process of many endogenous and exogenous moleculars, especially in drug metabolism. The great individual variations of the CYP450 enzymes among human subjects have been showed. In addition to the genetic factors, food and other environmental factors may also affect the activity and expression of CYP450 enzymes, which ultimately lead to the increased possibility of adverse reactions or toxicity. This review article summarizes the recent literatures with interests in the effects of food on cytochrome P450.

Key words: food, cytochrome p450, inhibition, induction

中图分类号:

R968

章冉冉, 阳国平, 荆宁宁, 黄洁, 黄路, 王艳. 食物对细胞色素P450药物代谢酶的影响[J]. 中国临床药理学与治疗学, 2014, 19(2): 200-205.

ZHANG Ran-ran, YANG Guo-ping, JING Ning-ning, HUANG Jie, HUANG Lu, WANG Yan. Effects of food on Cytochrome P450 drug metabolic enzymes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(2): 200-205.

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