多药耐药相关蛋白1及其与肿瘤关系的研究进展

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (3): 351-355.

多药耐药相关蛋白1及其与肿瘤关系的研究进展

李俊¹, 蒋葵², 张学梅¹

¹大连大学医学院,大连 116622,辽宁;
²大连医科大学附属第二医院肿瘤科,大连 116027,辽宁

收稿日期:2013-08-01 修回日期:2014-02-24 出版日期:2014-03-26 发布日期:2014-04-10
通讯作者: 张学梅,女,副教授,硕士生导师,研究方向:药理学和基因工程抗体的制备。E-mail: zhangxue_m@163.com
作者简介:李俊,男,硕士研究生,研究方向:基因工程抗体的制备。E-mail: lijunedu@163.com
基金资助:
“十一五”国家科技支撑计划项目 (2009BAK61B04)

Adervances in the research of multidrug resistance-associated protein 1 and its relationship with tumor

LI Jun¹, JIANG Kui², ZHANG Xue-mei¹

¹Medical College of Dalian University, Dalian 116622,Liaoning,China;
²Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning ,China

Received:2013-08-01 Revised:2014-02-24 Online:2014-03-26 Published:2014-04-10

摘要/Abstract

摘要： 多药耐药(MDR)是导致临床肿瘤化疗失败的重要原因。多药耐药相关蛋白1(MRP1/ABCC1)被认为是介导肿瘤多药耐药的主要跨膜转运蛋白之一。探究MRP1/ABCC1的结构、功能,以及与肿瘤的关系,有利于指导临床合理用药和肿瘤预后的评估。

关键词: 多药耐药相关蛋白1, 多药耐药, 肿瘤

Abstract: Multidrug resistance (MDR) is a major impediment to the cancer chemotherapy. Multidrug resistance associated protein 1(MRP1/ABCC1) is thought to be one of the main transmembrane proteins that mediate tumor multidrug resistance. Exploring its structure and function,as well as the relationship between MRP1/ABCC1 and tumor, will be beneficial to provide an optimal strategy and evaluate the prognosis of tumor.

Key words: multidrug resistance associated protein 1, multidrug resistance, tumor

中图分类号:

R968

李俊, 蒋葵, 张学梅. 多药耐药相关蛋白1及其与肿瘤关系的研究进展[J]. 中国临床药理学与治疗学, 2014, 19(3): 351-355.

LI Jun, JIANG Kui, ZHANG Xue-mei. Adervances in the research of multidrug resistance-associated protein 1 and its relationship with tumor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(3): 351-355.

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