巨核细胞程序性死亡在系统性红斑狼疮合并血小板减少机制中的研究进展

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (5): 579-583.

巨核细胞程序性死亡在系统性红斑狼疮合并血小板减少机制中的研究进展

窦蕾, 徐亮

皖南医学院附属弋矶山医院风湿免疫科,芜湖 241001,安徽

收稿日期:2013-09-23 修回日期:2014-04-25 出版日期:2014-05-26 发布日期:2014-06-05
通讯作者: 徐亮,男,主任医师,教授,硕士生导师,研究方向:风湿免疫病。Tel: 13956174096 E-mail: xuliang-57@sohu.com
作者简介:窦蕾,女,研究生在读,研究方向:风湿免疫病。Tel: 13805532944 E-mail: doulei1987@126.com
基金资助:
国家自然科学基金项目(30571740)

Development of the megakaryocyte programmed cell death in Systemic lupus erythematosus complicated with thrombocytopenia

DOU Lei, XU Liang

Department of Rheumatism Immunity, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China

Received:2013-09-23 Revised:2014-04-25 Online:2014-05-26 Published:2014-06-05

摘要/Abstract

摘要： 系统性红斑狼疮(systemic lupus erythmatosus,SLE)是一种以免疫炎症为特点的自身免疫性疾病,血小板减少是SLE常见的血液系统表现之一。SLE合并血小板减少的发病机制一直是研究的难点与热点。随着细胞的程序性死亡与SLE及自身免疫性疾病关系的研究,巨核细胞程序性死亡在SLE合并血小板减少的作用显得尤为重要。本文就巨核细胞程序性死亡在SLE合并血小板减少中发病中的研究进展作一综述。

关键词: 巨核细胞, SLE, 血小板, 程序性死亡

Abstract: Systemic lupus erythematosus (SLE) is a kind of autoimmune disease which is characterized by immune inflammatory, thrombocytopenia is one of the common performances of SLE. The pathogenesis of SLE complicated with thrombocytopenia is always a difficult and hot problem.With the study of programmed cell death in SLE and autoimmune diseases, the programmed cell death of megakaryocytes is significant in the pathogenesis of SLE complicated with thrombocytopenia. This review is focus on the development of megakaryocyte programmed cell death in SLE complicated with thrombocytopenia.

Key words: megakaryocyte, systemic lupus erythematosus, platelet, programmed cell death

中图分类号:

R593.2

窦蕾, 徐亮. 巨核细胞程序性死亡在系统性红斑狼疮合并血小板减少机制中的研究进展[J]. 中国临床药理学与治疗学, 2014, 19(5): 579-583.

DOU Lei, XU Liang. Development of the megakaryocyte programmed cell death in Systemic lupus erythematosus complicated with thrombocytopenia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(5): 579-583.

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