Survivin蛋白在抗肿瘤治疗中的研究进展

摘要/Abstract

摘要： Survivin是迄今为止发现的与肿瘤最相关的特异性蛋白,其在几乎所有人类肿瘤中的表达都是上调的。由于它在肿瘤恶性程度方面的可上调性和在肿瘤的凋亡、增殖、血管新生方面的不可或缺性,survivin被认为可以作为抗肿瘤治疗的新靶点。目前正在进行研究的针对survivin的抗肿瘤制剂包括反义寡核苷酸类、siRNA、核酶、免疫治疗和小分子等。针对这些制剂的一些临床I/II期临床试验正在进行中。Survivin蛋白拮抗剂有望与传统的抗肿瘤治疗药物联合使用,发挥更好的治疗效果。

关键词: survivin, 抗肿瘤, 治疗, 凋亡

Abstract: Survivin is a cancer-specific protein, and it upregulated in almost all human tumors. Because of its upregulation in malignancy and its key role in apoptosis, proliferation and angiogenesis, survivin is considered as a new target for anti-cancer therapies. Strategies under the research to target survivin include antisense oligonucleotides, siRNA, ribozymes, immunotherapy and small molecular weight molecules. Several phase I/II clinical trials targeting survivin are currently ongoing. The usage of survivin antagonists combined with conventional therapies might achieve better therapeutic effect.

Key words: survivin, anti-cancer, therapy, apoptosis

中图分类号:

R73
R966

储冀汝, 谢海棠, 李娟, 钟正灵. Survivin蛋白在抗肿瘤治疗中的研究进展[J]. 中国临床药理学与治疗学, 2014, 19(7): 835-840.

CHU Ji-ru, XIE Hai-tang, LI Juan, ZHONG Zheng-ling. Research development in surivin protein on anti-cancer therapies[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(7): 835-840.

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