老年2型糖尿病血尿酸水平与骨密度的相关性研究

中国临床药理学与治疗学 ›› 2015, Vol. 20 ›› Issue (5): 567-570.

老年2型糖尿病血尿酸水平与骨密度的相关性研究

阮园¹, 吴天凤¹, 袁放¹, 文晓林²

¹浙江医院内分泌科, ²浙江医院双能骨密度室,杭州 310013,浙江

收稿日期:2014-12-12 修回日期:2015-05-07 发布日期:2015-06-11
作者简介:阮园,女,主治医师,主要从事内分泌科临床工作。Tel: 18158102110 E-mail: porpoises88@hotmail.com

Relationship between uric acid and bone mineral density in elderly type 2 diabetes

RAUN Yuan¹, WU Tian-feng¹, YUAN Fang¹, WEN Xiao-lin²

¹ Department of Endocrinology, ² Department of Bone Mineral Density, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China

Received:2014-12-12 Revised:2015-05-07 Published:2015-06-11

摘要/Abstract

摘要： 目的: 探讨老年2型糖尿病患者(T2DM)血尿酸水平(SUA)与骨密度值(BMD)的关系。方法: 测定200例(男性110例,女性90例)老年2型糖尿病患者SUA及相关临床资料,应用双能X线测定BMD,根据性别分为男性组及女性组,根据SUA水平分为高尿酸血症组及正常血尿酸组,分析各组BMD差异及SUA与BMD的相关性。结果: 老年2型糖尿病患者中,男性各部位BMD均高于女性。SUA与腰椎BMD存在正相关关系(r=0.236,P<0.05),SUA是影响腰椎BMD的独立危险因素(标准偏回归系数β'=0.294,P<0.01),而体重指数和血脂水平主要影响股骨的BMD。结论: 在老年T2DM患者中,维持一定的SUA水平有利于预防骨量丢失。

关键词: 尿酸, 骨密度, 老年, 2型糖尿病

Abstract: AIM: To study the relationship between uric acid (SUA) and bone mineral density　(BMD) in elderly type 2 diabetes.METHODS: The clinical data, SUA, and BMD (determined by dual energy x-ray absorptiometry [DXA]) of two hundred elderly type 2 diabetes patients were obtained. All the patients were divided into male group and female group; also they were further subdivided into hyperuricemia and normouricemia groups according to the level of SUA.The association between SUA and BMD from the respective groups were compared and analyzedRESULTS: SUA was positively related to BMD of lumbar spine (L_2-4) in elderly type 2 diabetes (r=0.236,P<0.05). BMD of males was significantly higher than that of females. SUA was an independent risk factor for BMD of L_2-4(β'=0.294,P<0.01). BMI and HDL-C were independent risk factors for BMD of t thigh bone.CONCLUSION: Maintaining certain blood uric acid level will be helpful to prevent osteoporosis in elderly type 2 diabetes.

Key words: uric acid, bone mineral density, elderly, type 2 diabetes

中图分类号:

阮园, 吴天凤, 袁放, 文晓林. 老年2型糖尿病血尿酸水平与骨密度的相关性研究[J]. 中国临床药理学与治疗学, 2015, 20(5): 567-570.

RAUN Yuan, WU Tian-feng, YUAN Fang, WEN Xiao-lin. Relationship between uric acid and bone mineral density in elderly type 2 diabetes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(5): 567-570.

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