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中国临床药理学与治疗学 ›› 2022, Vol. 27 ›› Issue (7): 808-813.doi: 10.12092/j.issn.1009-2501.2022.07.012

• 综述与讲座 • 上一篇    下一篇

吸入性甲氧氟烷的临床应用及研究进展

戴静怡,王晶晶,张菁,郁继诚,李南洋,黄志伟   

  1. 复旦大学附属华山医院,I期临床研究室,上海 200040
  • 收稿日期:2022-05-12 修回日期:2022-07-18 出版日期:2022-07-26 发布日期:2022-08-11
  • 通讯作者: 王晶晶,女,本科,主管护师,主要从事I期临床研究工作。 E-mail: 821021316@qq.com
  • 作者简介:戴静怡,女,本科,主要从事I期临床研究工作。 E-mail: 15026697560@163.com
  • 基金资助:
    “重大新药创制”科技重大专项(“十三五”);上海市领军人才(编号:03)

Clinical application and research progress of inhaled methoxyflurane

DAI Jingyi, WANG Jingjing, ZHANG Jing, YU Jicheng, LI Nanyang, HUANG Zhiwei   

  1. Laboratory of Phase I Clinical Research, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2022-05-12 Revised:2022-07-18 Online:2022-07-26 Published:2022-08-11

摘要: 甲氧氟烷作为氟化烃类麻醉剂,在麻醉剂量下可能会导致肾功能损害等严重的不良反应,但其亚麻醉剂量下产生的镇痛作用安全性好,耐受性高,是短期急性镇痛的治疗选择。本文从甲氧氟烷的药代动力学、临床有效性、不良反应及临床应用四方面进行叙述,探讨了甲氧氟烷作为镇痛剂在临床应用的可及性。甲氧氟烷作为吸入性镇痛剂使用方便,无需通过静脉给药即可为患者提供紧急镇痛,是门急诊紧急镇痛的良好选择。

关键词: 甲氧氟烷, 吸入镇痛剂, 药代动力学

Abstract: As a fluorinated hydrocarbon anesthetic, methoxyflurane may cause serious adverse reactions such as renal damage under anesthetic doses, but its analgesic effect at sub-anaesthetic doses is safe, high tolerability, and short-term acute Good choice for analgesia. This article describes the pharmacokinetics, clinical validity, adverse reactions and clinical application of methoxyflurane, and explores the feasibility of methoxyflurane as an analgesic in clinical application. Methoxyflurane is convenient to use as an inhaled analgesic. It can provide patients with emergency analgesia without intravenous administration. It is a good choice for emergency analgesia in pre-hospital and emergency settings.

Key words: methoxyflurane, inhaled analgesics, pharmacokinetics

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