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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (7): 977-983.doi: 10.12092/j.issn.1009-2501.2025.07.013

• 综述与讲座 • 上一篇    下一篇

常用中成药治疗乳腺癌的临床应用及作用机制研究进展

李闪闪1,2,魏丹丹3,康涵钰2,刘晓鹏2,燕树勋1,蒋士卿2   

  1. 1河南中医药大学第一附属医院内分泌科,郑州  450000,河南;2河南中医药大学第一临床医学院,郑州  450000,河南;3河南中医药大学第一附属医院针灸疼痛科,郑州  450000,河南
  • 收稿日期:2024-09-03 修回日期:2025-01-18 出版日期:2025-07-26 发布日期:2025-07-02
  • 通讯作者: 燕树勋,男,博士,教授,主任医师,博士生导师,博士后合作导师,研究方向:从事中西医结合防治内分泌疾病的研究。 E-mail: ysx982001@163.com 蒋士卿,男,博士,教授,主任医师,博士生导师,博士后合作导师,研究方向:从事中西医结合防治恶性肿瘤的研究。 E-mail: jiangshiqing66@126.com
  • 作者简介:李闪闪,女,研究生,住院医师,研究方向:从事中西医结合防治恶性肿瘤及内分泌的临床与科研。 E-mail: 3028948497@qq.com
  • 基金资助:
    国家科技创新2030“癌症、心脑血管、呼吸和代谢性疾病防治研究”重大项目(2023ZD0502701);全国老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)

Research progress on the clinical application and mechanism of commonly used traditional Chinese medicine in the treatment of breast cancer

LI Shanshan1,2, WEI Dandan3, KANG Hanyu2, LIU Xiaopeng2, YAN Shuxun1, JIANG Shiqing2   

  1. 1Endocrinology Department Ward of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China; 2The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China; 3Acupuncture Pain Department of First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China
  • Received:2024-09-03 Revised:2025-01-18 Online:2025-07-26 Published:2025-07-02

摘要:

乳腺癌是临床常见的妇科肿瘤,据2022年全球癌症数据统计,在全球癌症新发病例中,乳腺癌发病率位居第二位。现代医学常采用手术、化疗等方法,虽有一定疗效,但存在耐药率高、不良反应大等诸多问题。中成药具有广泛的抗癌作用。研究发现,参一胶囊、平消胶囊、贞芪扶正颗粒等广泛用于乳腺癌的治疗,可以通过抑制细胞增殖、侵袭、转移、抑制血管生成、逆转细胞耐药、抑制癌前病变等发挥治疗乳腺癌的作用。同时,口服中成药联合其他中药复方、中药汤剂或者现代医学治疗可以提高患者的生活质量、降低不良反应等。目前关于中成药治疗乳腺癌的研究较多,但缺乏系统总结,故本研究通过系统综述中成药辅助治疗乳腺癌的作用机制及临床应用,以为临床用药提供参考。

关键词: 乳腺癌, 中成药, 作用机制, 临床应用 

Abstract:

Breast cancer is a common clinical gynecological tumor. According to the 2022 global cancer data statistics, breast cancer ranks second in terms of incidence among newly diagnosed cancer cases worldwide. Modern medicine often adopts surgical operation, chemotherapy, and other methods, which have certain efficacy but also many problems such as high drug resistance rates and significant adverse reactions. Chinese patent medicines exhibit extensive anticancer effects. The study found that Shenyi Capsule, Pingxiao Capsule, and Zhenqi Fuzheng Granules were widely used in the treatment of breast cancer, exerting therapeutic effects on breast cancer by inhibiting cell proliferation, invasion, and metastasis, suppressing angiogenesis, reversing cellular drug resistance, and inhibiting precancerous lesions. Meanwhile, the oral administration of Chinese patent medicines in combination with other traditional Chinese medicine (TCM) compounds, TCM decoctions, or modern medical treatments can improve patients' quality of life and reduce adverse reactions. Currently, there are numerous studies on the treatment of breast cancer with Chinese patent medicines, but a systematic summary is lacking. Therefore, this study conducted a systematic review of the mechanisms of action and clinical applications of Chinese patent medicines as adjuvant therapy for breast cancer, aiming to provide guidance for clinical medication.

Key words: breast cancer, Chinese patent medicine, mechanism of action, clinical application

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