巨噬细胞极化与肠道菌群及其代谢产物在器官损伤中相关研究进展

doi:10.12092/j.issn.1009-2501.2026.01.014

中国临床药理学与治疗学 ›› 2026, Vol. 31 ›› Issue (1): 125-132.doi: 10.12092/j.issn.1009-2501.2026.01.014

• 综述与讲座 • 上一篇

巨噬细胞极化与肠道菌群及其代谢产物在器官损伤中相关研究进展

文一如¹(), 杨金拉姆¹, 美嘎¹, 李娜², 录亚鹏², 张琰², 刘婕婷²^,*()

1. 兰州大学第二医院（第二临床医学院），兰州 730000，甘肃
2. 兰州大学第二医院（第二临床医学院）麻醉科，兰州 730000，甘肃

收稿日期:2024-12-08 修回日期:2025-02-22 出版日期:2026-01-26 发布日期:2026-02-13
通讯作者: 刘婕婷 E-mail:wenyiru975@163.com;49005110@qq.com
作者简介:文一如，女，硕士研究生，研究方向：围术期器官保护。E-mail：wenyiru975@163.com
基金资助:
甘肃省自然科学基金资助项目（22JR11RA049）；兰州大学第二医院（第二临床医学院）萃英科技创新计划（CY2024-MS-A08）

Progress in research on macrophage polarization, intestinal flora and their metabolites in organ injury

Yiru WEN¹(), Jinlamu YANG¹, Ga MEI¹, Na LI², Yapeng LU², Yan ZHANG², Jieting LIU²^,*()

1. The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu, China
2. Dpartment of Anesthesiology, The Second Hospital & Clinical Medical School, Lanzhou university, Lanzhou 730000, Gansu, China

Received:2024-12-08 Revised:2025-02-22 Online:2026-01-26 Published:2026-02-13
Contact: Jieting LIU E-mail:wenyiru975@163.com;49005110@qq.com

摘要/Abstract

摘要：

巨噬细胞极化和肠道菌群及其代谢产物是近年来的研究热点，一些已发表的研究表明，巨噬细胞极化与肠道菌群及其代谢产物具有一定的关联。肠道菌群及其代谢产物可诱导巨噬细胞向M1或M2型极化，从而产生促炎或抗炎反应，而这些反应又与器官损伤密切相关。本文就巨噬细胞极化与肠道菌群及其代谢产物在器官损伤中的相关研究作一综述，总结巨噬细胞极化的机制及相关通路，探讨肠道菌群及其代谢产物对巨噬细胞极化的影响以及其在相关疾病和器官损伤中的作用，以期为器官损伤机制及相应保护措施的研究提供新的思路。

关键词: 巨噬细胞极化, 肠道菌群, 代谢产物, 炎症反应, 器官损伤

Abstract:

Macrophage polarization, intestinal flora and their metabolites have emerged as research hotspots in recent years. Several published studies have shown that there is a certain correlation between macrophage polarization and intestinal flora as well as their metabolites. Intestinal flora and their metabolites can induce macrophages to polarize into M1 or M2 phenotypes, thereby triggering pro-inflammatory or anti-inflammatory responses, which are closely related to organ injury. This review summarizes the relevant research on macrophage polarization, intestinal flora, and their metabolites in organ injury. It elaborates on the mechanisms and related pathways of macrophage polarization, explores the regulatory effects of intestinal flora and their metabolites on macrophage polarization, and discusses their roles in related diseases and organ injury. The aim is to provide new insights for the research on the mechanisms of organ injury and corresponding protective strategies.

Key words: macrophage polarization, intestinal flora, metabolites, inflammation, organ injury

中图分类号:

文一如, 杨金拉姆, 美嘎, 李娜, 录亚鹏, 张琰, 刘婕婷. 巨噬细胞极化与肠道菌群及其代谢产物在器官损伤中相关研究进展[J]. 中国临床药理学与治疗学, 2026, 31(1): 125-132.

Yiru WEN, Jinlamu YANG, Ga MEI, Na LI, Yapeng LU, Yan ZHANG, Jieting LIU. Progress in research on macrophage polarization, intestinal flora and their metabolites in organ injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(1): 125-132.

图/表 2

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巨噬细胞极化与肠道菌群及其代谢产物在器官损伤中相关研究进展

Progress in research on macrophage polarization, intestinal flora and their metabolites in organ injury

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