欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2026, Vol. 31 ›› Issue (3): 428-432.doi: 10.12092/j.issn.1009-2501.2026.03.015

• 综述与讲座 • 上一篇    

新型抗精神病药KarXT

刘鑫1(), 刘小琳1, 周亚楠1, 翟金国2,*()   

  1. 1. 山东省戴庄医院,济宁 272051,山东
    2. 济宁医学院精神卫生学院,济宁 272067,山东
  • 收稿日期:2025-03-07 修回日期:2025-04-25 出版日期:2026-03-26 发布日期:2026-04-03
  • 通讯作者: 翟金国 E-mail:401926414@qq.com;zhaijinguo@163.com
  • 作者简介:刘鑫,男,硕士研究生,住院医师,研究方向:临床精神病学。E-mail:401926414@qq.com
  • 基金资助:
    山东省自然科学基金项目(ZR2017LH036);济宁市重点研发计划项目(2024YXNS200)

New antipsychotic drug KarXT

Xin LIU1(), Xiaolin LIU1, Yanan ZHOU1, Jinguo ZHAI2,*()   

  1. 1. Shandong Daizhuang Hospital, Jining 272051, Shandong, China
    2. School of Mental Health, Jining Medical University, Jining 272067, Shandong, China
  • Received:2025-03-07 Revised:2025-04-25 Online:2026-03-26 Published:2026-04-03
  • Contact: Jinguo ZHAI E-mail:401926414@qq.com;zhaijinguo@163.com

摘要:

目前抗精神病药主要针对多巴胺受体起作用,对于阴性症状、认知症状的改善有限,存在锥体外系不良反应、代谢综合征、内分泌紊乱等不良反应,部分患者无法耐受。近期FDA批准了新型抗精神病药KarXT(商品名为Cobenfy)用于治疗成人精神分裂症,该药通过作用于M1、M4型毒蕈碱乙酰胆碱受体发挥作用。目前临床试验结果表明,KarXT能改善精神分裂症的阳性症状、阴性症状和认知损害,不良反应主要为胃肠道症状。本文对KarXT的药理机制、药代动力学、临床评价、安全性等方面的最新文献进行了综述。

关键词: 抗精神病药, 临床试验, 药物评价, 药物相关性副作用和不良反应, 认知损害

Abstract:

At present, antipsychotic drugs mainly act on dopamine receptors, but the improvement of negative symptoms and cognitive symptoms is limited. There are extrapyramidal adverse reactions, metabolic syndrome, endocrine disorders and other adverse reactions, which some patients can not tolerate. KarXT (trade name Cobenfy), a novel antipsychotic drug approved by the FDA for the treatment of schizophrenia in adults, acts on M1 and M4 muscarinic acetylcholine receptors (mAChR). The results of current clinical trials have shown that KarXT can improve the positive symptoms, negative symptoms and cognitive impairment of schizophrenia, and the adverse reactions are mainly gastrointestinal symptoms. This article reviews the latest literature on the pharmacological mechanism, pharmacokinetics, clinical evaluation, and safety of KarXT.

Key words: antipsychotic agents, clinical trial, drug evaluation, drug-related side effects and adverse reactions, cognitive dysfunction

中图分类号: